Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria
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DOI：
10.1021/nn101390x
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发表时间：
2010-10-01
期刊：
影响因子：
17.1
通讯作者：
Ghaderi, Elham
中科院分区：
文献类型：
--
作者：
Akhavan, Omid;Ghaderi, Elham
研究了革兰氏阳性和革兰氏阴性模型的细菌纳米片的石墨烯纳米片的细菌毒性。氧化石墨烯是通过通过化学去角质方法合成的Mg2+氧化烯纳米片的电泳沉积获得的。根据测量细菌的细胞质材料的外流，发现细菌与细菌与纳米瓦尔的极端边缘直接接触引起的细菌的细胞膜损伤是细菌失活的有效机制。在这方面，与缺乏革兰氏阳性的金黄色葡萄球菌相比，革兰氏阴性大肠杆菌具有外膜的革兰氏阴性大肠杆菌对细胞膜损伤的抵抗力更大。此外，与未还原的氧化石墨烯纳米瓦尔相比，氢氮还原的氧化石墨烯对细菌的毒性更大。在接触相互作用期间，还将还原纳米瓦的纳米瓦的抗菌活性更好地分配给了细菌和还原纳米层的更锐利的边缘之间的更好的电荷转移。
Bacterial toxicity of graphene nanosheets in the form of graphene nanowalls deposited on stainless steel substrates was investigated for both Gram-positive and Gram-negative models of bacteria. The graphene oxide nanowalls were obtained by electrophoretic deposition of Mg2+-graphene oxide nanosheets synthesized by a chemical exfoliation method. On the basis of measuring the efflux of cytoplasmic materials of the bacteria, it was found that the cell membrane damage of the bacteria caused by direct contact of the bacteria with the extremely sharp edges of the nanowalls was the effective mechanism in the bacterial inactivation. In this regard, the Gram-negative Escherichia coli bacteria with an outer membrane were more resistant to the cell membrane damage caused by the nanowalls than the Gram-positive Staphylococcus aureus lacking the outer membrane. Moreover, the graphene oxide nanowalls reduced by hydrazine were more toxic to the bacteria than the unreduced graphene oxide nanowalls. The better antibacterial activity of the reduced nanowalls was assigned to the better charge transfer between the bacteria and the more sharpened edges of the reduced nanowalls, during the contact interaction.