Imaging chorioretinal vascular disease
Imaging chorioretinal vascular disease
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DOI：
10.1038/eye.2009.309
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发表时间：
2010-03-01
期刊：
影响因子：
3.9
通讯作者：
Sadda, S. R.
中科院分区：
文献类型：
--
作者：
Keane, P. A.;Sadda, S. R.
自从40多年前首次描述以来，荧光素血管造影术在脉络膜视网膜血管疾病的诊断和治疗中发挥了至关重要的作用，如新生血管性老年性黄斑变性。虽然荧光素血管造影术可以精细地显示视网膜微循环，但脉络膜循环的可视化受到更多限制。此外，荧光素血管造影术只能提供有关血管疾病的功能后果的最低限度的信息，充其量只能对视网膜厚度进行半定量评估。近年来，其他脉络膜视网膜成像方法的发展，如吲哚青绿血管造影、眼底自发荧光和光学相干断层扫描(OCT)，已经解决了许多这样的问题。特别是，OCT已经成为玻璃体视网膜专家不可或缺的工具，因为它允许以非侵入性方式获得高分辨率的神经感觉性视网膜断层图像。最新一代的商用OCT技术-光谱域OCT-提供高速扫描，允许完全覆盖黄斑区域，生成三维视网膜重建，并为来访之间的比较提供精确的图像配准。光谱域OCT的高速还有助于B扫描平均，从而减少斑点噪声伪影，并允许无与伦比的外部视网膜和脉络膜的可视化。在不久的将来，OCT技术的进一步进步(如多普勒OCT)可能会极大地提高脉络膜视网膜血管疾病患者的诊断和治疗水平。Eye(2010)24422-427；doi：10.1038/ye.2009.309；2009年12月11日在线发布
Since its first description more than 40 years ago, fluorescein angiography had a crucial role in the diagnosis and management of chorioretinal vascular disorders such as neovascular age-related macular degeneration. Although fluorescein angiography permits visualization of the retinal microcirculation in exquisite detail, visualization of the choroidal circulation is more limited. Moreover, fluorescein angiography provides only minimal information regarding the functional consequences of vascular disease and allows, at best, only semi-quantitative assessment of retinal thickness. In recent years, the development of other chorioretinal imaging modalities, such as indocyanine green angiography, fundus autofluorescence, and optical coherence tomography (OCT), has addressed many of these issues. In particular, OCT has become an integral tool for vitreoretinal specialists as it allows high-resolution cross-sectional images of the neurosensory retina to be obtained in a non-invasive manner. The latest generation of commercial OCT technology-spectral domain OCT-offers high-speed scanning that allows complete coverage of the macular area, generation of three-dimensional retinal reconstructions, and precise image registration for inter-visit comparisons. The high speed of spectral domain OCT also facilitates B-scan averaging, which reduces speckle noise artefact and allows unparalleled visualization of the outer retina and choroid. In the near future, further advances in OCT technology (eg Doppler OCT) are likely to dramatically enhance the diagnosis and management of patients with chorioretinal vascular disease. Eye (2010) 24, 422-427; doi:10.1038/eye.2009.309; published online 11 December 2009