Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
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DOI：
10.1016/j.bpg.2013.03.005
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发表时间：
2013-02-01
影响因子：
3.2
通讯作者：
Reinisch, Walter
中科院分区：
文献类型：
--
作者：
Berry, David;Reinisch, Walter
人体肠道具有复杂的微生物生态系统，对宿主的营养和健康具有多种重要功能。广泛的研究表明，炎症性肠病(IBD)患者肠道微生物区系的组成发生了变化。与IBD相关的肠道微生物群通常降低了物种丰富度和多样性，降低了时间稳定性，并破坏了分泌的粘液层结构。多项研究已经确定了某些在IBD中富含或枯竭的细菌分类群，包括肠杆菌科、瘤胃球菌、硫化弧菌(富含)和普鲁斯尼茨费卡利杆菌、乳螺科和阿克曼西亚(贫乏)。此外，一些分类群的相对丰度似乎与已建立的疾病活动标志相关，如肠杆菌科(富集型)和乳螺科(贫乏型)。因此，粪便微生物群落组成的标志性变化可能被证明是有价值的诊断生物标志物，特别是对于纵向监测疾病活动和对治疗的反应。(C)2013爱思唯尔有限公司。保留所有权利。
The human intestine harbours a complex microbial ecosystem that performs manifold functions important to the nutrition and health of its host. Extensive study has revealed that the composition of the intestinal microbiota is altered in individuals with inflammatory bowel disease (IBD). The IBD associated intestinal microbiota generally has reduced species richness and diversity, lower temporal stability, and disruption of the secreted mucus layer structure. Multiple studies have identified certain bacterial taxa that are enriched or depleted in IBD including Enterobacteriaceae, Ruminococcus gnavus, and Desulfovibrio (enriched) and Faecalibacterium prausnitzii, Lachnospiraceae, and Akkermansia (depleted). Additionally, the relative abundance of some taxa appears to correlate with established markers of disease activity such as Enterobacteriaceae (enriched) and Lachnospiraceae (depleted). Signature shifts in fecal microbial community composition may therefore prove to be valuable as diagnostic biomarkers, particularly for longitudinal monitoring of disease activity and response to treatments. (c) 2013 Elsevier Ltd. All rights reserved.