Factors associated with the use of probiotics in patients with inflammatory bowel disease.
Factors associated with the use of probiotics in patients with inflammatory bowel disease.
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DOI：
10.12688/f1000research.2-69.v1
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Beales IL
中科院分区：
文献类型：
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作者：
Agathou CL;Beales IL
背景：益生菌制剂在英国得到了大力推广，并可广泛购买。益生菌对胃肠道功能有多种作用，对炎症性肠病（IBD）可能有有益甚至有害的影响。IBD患者通常使用各种补充和替代药物，但专门使用益生菌的数据要少得多。 目的：调查IBD患者目前使用益生菌的情况，并确定与益生菌使用相关的因素。 方法：在英国教学医院接受常规护理的IBD受试者进行了标准化结构化的访谈。目前使用的益生菌进行了探讨，并检查患者和疾病相关因素。IBD相关的生活质量进行了评估与炎症性肠病问卷（S-IBDQ）。使用对数回归来探索与益生菌使用相关的因素。 结果：40名受试者接受了访谈，益生菌的使用是普遍的，40%的受试者是经常使用者。益生菌的使用与IBD自诊断以来的持续时间较短、克罗恩病的诊断、18岁后的正规教育和S-IBDQ评估的生活质量较低显著相关。对制剂味道的偏好是使用益生菌的常见原因，也是潜在的疾病修饰作用。非使用者报告说，制剂费用和对疗效的怀疑是不使用的主要原因。 结论：在本研究中，益生菌的使用在IBD患者中很常见。几个与患者和疾病相关的因素，包括较低的生活质量，与益生菌的使用有关。
Background: Probiotic preparations are heavily promoted in the United Kingdom and are widely available to purchase. Probiotics have multiple effects on gastrointestinal functions and may have beneficial or even harmful effects in inflammatory bowel disease (IBD). Various complementary and alternative medicines are commonly used by IBD patients but there is much less data specifically on the use of probiotics. Aim: To examine the current use of probiotics by IBD patients and determine the factors associated with probiotic use. Methods: Subjects with IBD undergoing routine care at a UK teaching hospital underwent a standardized structured questionnaire-interview. Current use of probiotics was explored and patient- and disease-related factors examined. IBD-related quality of life was assessed with the short inflammatory bowel disease questionnaire (S-IBDQ). Logistical regression was used to explore factors associated with probiotic use. Results: Forty subjects were interviewed. Probiotic use was common, 40% of subjects being regular users. Probiotic use was significantly associated with a shorter duration of IBD since diagnosis, a diagnosis of Crohn’s disease, formal post-18 education and lower quality of life as assessed by the S-IBDQ. A preference for the taste of the preparation was as common a reason for using probiotics as were potential disease modifying effects. Non-users reported that the costs of the preparations and doubts about efficacy were the primary reasons for non-use. Conclusions: In this study probiotic use was common in IBD patients. Several patient- and disease- related factors, including a lower perceived quality of life, were associated with the use of probiotics.