Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction.
Plane warts under spontaneous regression. Immunopathologic study on cellular constituents leading to the inflammatory reaction.
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平面疣自然消退。
DOI：
10.1001/archderm.1986.01660180061015
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发表时间：
1986
影响因子：
--
通讯作者：
M. Yamada
中科院分区：
文献类型：
--
作者：
K. Iwatsuki;H. Tagami;M. Takigawa;M. Yamada
免疫组织化学显示，消退期扁平疣的细胞浸润物主要由淋巴细胞和单核巨噬细胞组成。可见大量浸润性T淋巴细胞。免疫电子显微镜观察发现T淋巴细胞的辅助型/诱导型和抑制型/细胞毒表型均可见于皮损中。OKT6阳性细胞见于真皮和表皮。此外，在变态反应性接触性皮炎中，可以看到T淋巴细胞与郎格汉斯细胞样细胞的结合。在受损的表皮角质形成细胞附近发现了淋巴细胞和少量单核巨噬细胞，其图像被描述为卫星细胞坏死，这是侵略者细胞毒性反应的标志。这些发现表明，在扁平疣消退的过程中，针对感染病毒的角质形成细胞的特异性细胞免疫发生了。
Immunohistologically, cellular infiltrates in regressing plane warts were mainly composed of lymphocytes and mononuclear phagocytes. There were many infiltrating T lymphocytes. Immunoelectron microscopic observation demonstrated that both helper/inducer and suppressor/cytotoxic phenotypes of T lymphocytes infiltrated in the lesions. OKT6-positive cells were observed in the dermis as well as in the epidermis. Moreover, as noted in allergic contact dermatitis, the apposition of T lymphocytes to Langerhans' cell-like cells could be seen. Lymphocytes and a small number of mononuclear phagocytes were found adjacent to damaged keratinocytes in the epidermis, the picture of which has been described as satellite cell necrosis, a hallmark of cytotoxic reaction by aggressors. These findings suggest that specific cell-mediated immunity against virus-infected keratinocytes takes place in the process of regressing plane warts.