Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population.
Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population.
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DOI：
10.3390/nu14020382
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发表时间：
2022-01-17
期刊：
影响因子：
5.9
通讯作者：
Vimaleswaran KS
中科院分区：
文献类型：
--
作者：
Isgin-Atici K;Alathari BE;Turan-Demirci B;Sendur SN;Lay I;Ellahi B;Alikasifoglu M;Erbas T;Buyuktuncer Z;Vimaleswaran KS
以前的研究已经指出了维生素D状态和代谢特征之间的联系，然而，尚未提供一致的证据。这项横断面研究采用营养遗传学方法，调查了396名年龄在24-50岁之间的无关土耳其成年人的代谢遗传风险评分（GRS）和饮食摄入量对血清25-羟基维生素D [25（OH）D]浓度之间的相互作用。代谢性GRS ≥ 1危险等位基因的患者血清25（OH）D浓度显著低于代谢性GRS < 1危险等位基因的患者（p = 0.020）。代谢-GRS和膳食脂肪摄入量（能量%）对血清25（OH）D水平有显著的交互作用（P交互作用= 0.040）。携带代谢-GRS ≥ 1风险等位基因并食用高脂肪饮食（≥38%能量= 122.3 ± 52.51 g/d）的参与者与食用低脂饮食（<38%能量= 82.5 ± 37.36 g/d）的参与者相比，血清25（OH）D浓度显著降低（p = 0.006）。总之，我们的研究表明，代谢GRS和膳食脂肪摄入量对血清25（OH）D水平之间存在一种新的相互作用，这强调了遵循目前的膳食脂肪摄入量建议（<35%总脂肪）对于降低土耳其人群维生素D缺乏症的患病率可能很重要。然而，在实施个性化饮食建议以维持最佳维生素D状态之前，需要进一步的大型研究来验证这种相互作用。
Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24–50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.
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DOI：
10.4161/19381980.2014.983401
发表时间：
2014-01
期刊：
Dermato-endocrinology
影响因子：
--
作者：
Cannell JJ;Grant WB;Holick MF
通讯作者：
Holick MF
影响因子：
4.7
作者：
Ebadi, Maryam;Montano-Loza, Aldo J.
通讯作者：
Montano-Loza, Aldo J.
影响因子：
4.6
作者：
AlFaris, Nora A.;AlKehayez, Nora M.;AlMudawah, Ebtisam S.
通讯作者：
AlMudawah, Ebtisam S.
影响因子：
2.8
作者：
Alathari BE;Sabta AA;Kalpana CA;Vimaleswaran KS
通讯作者：
Vimaleswaran KS
影响因子：
13.6
作者：
Buijsse, Brian;Boeing, Heiner;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf