Early phases of HIV type 1 infection.
Early phases of HIV type 1 infection.
复制标题
HIV 1 型感染的早期阶段。
DOI：
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发表时间：
1996
影响因子：
1.5
通讯作者：
B. Mathieson
中科院分区：
文献类型：
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作者：
M. D’Souza;B. Mathieson
举办了一个题为“艾滋病毒-1感染的早期阶段”的讲习班，以审查目前关于人类和动物模型中艾滋病毒感染早期阶段的免疫学和病毒学方面的研究，确定未来研究的研究，并促进生物医学界研究人员之间的合作。在成人感染中，当出现细胞毒性T淋巴细胞活性时，与血浆病毒血症测量的病毒载量下降相一致。然而，在新生儿感染中，在检测到细胞毒性T淋巴细胞之前的几个月，已经观察到病毒载量的初始下降。来自有限数量患者的免疫学数据表明，在HIV-1感染后早期检测到的CD8+细胞毒性T淋巴细胞可以识别几种HIV-1蛋白的表位：Env、Gag、Pol、Tat和Nef。关于体液抗体反应，抗env结合抗体出现在中和抗体之前，并不能预测中和活性的出现。中和抗体出现的时间是可变和不可预测的。初步数据表明，在许多病例中，早期病毒峰值载量并不能预测疾病进展，病毒的表型或毒力似乎是一个关键变量。然而，血浆中HIV-1 RNA的数量是同性恋男性HIV-1血清转化后结果的一个强大的CD4+ T细胞独立预测因子。在成人和婴儿中，早期的高病毒载量和持续的病毒血症往往伴随着无法产生有效的免疫反应，导致疾病快速进展。
A workshop entitled "Early Phases of HIV-1 Infection" was held to review current research on the immunological and virological aspects of early phases of HIV infection in humans and in animal models, to identify studies for future research, and to foster collaborations among investigators in the biomedical community. In infections of adults, the appearance of cytotoxic T lymphocyte activity, when present, coincides with a decrease in viral load as measured by plasma viremia. In neonatal infections, however, an initial decrease in viral load has been observed months before cytotoxic T lymphocytes are detected. Immunological data, from a limited number of patients, indicated that CD8+ cytotoxic T lymphocytes detected early after HIV-1 infection may recognize epitopes in any of several HIV-1 proteins: Env, Gag, Pol, Tat, and Nef. With regard to the humoral antibody response, anti-Env binding antibodies appear before neutralizing antibodies and do not predict the appearance of neutralizing activity. The time at which neutralizing antibody appears is variable and unpredictable. Preliminary data indicate that early viral peak load does not predict disease progression in many cases, and the phenotype or virulence of the virus appears to be a critical variable. However, the quantity of HIV-1 RNA in plasma is a strong CD4+ T cell-independent predictor of outcome following HIV-1 seroconversion in homosexual men. Early, high virus load with sustained viremia is often accompanied, in both adults and infants, by the inability to mount an effective immune response, resulting in rapid disease progression.