Toward a unifying theory of bone remodeling
Toward a unifying theory of bone remodeling
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DOI：
10.1016/s8756-3282(99)00241-0
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发表时间：
2000-01-01
期刊：
影响因子：
4.1
通讯作者：
Martin, RB
中科院分区：
文献类型：
--
作者：
Martin, RB
开发了一种理论来解决骨重塑的当前概念和观察之间的一些不一致。例如，观察结果表明，当机械负荷过低（即处于废弃状态）时，以及当机械负荷过高时，重塑都会增加，从而产生大量疲劳损伤，这与广泛持有的假设相反，即骨细胞产生的与机械负荷成比例的信号会刺激骨衬细胞激活重塑。新理论通过假设衬里细胞倾向于激活重塑，除非受到抑制信号的限制，并且机械激发的骨细胞信号发挥这种抑制功能，从而解决了这种差异。因此，当信号生成因负载减少而下降时，或者当信号生成或传输因负载过大而损坏而中断时，重构就会加剧。否则，通过生理负荷产生的抑制信号，重塑会保持在相对较低的水平。此外，假设抑制信号与 Marotti 提出的成骨细胞转化为骨细胞的机制相同，并导致骨基本多细胞单位再填充过程中并置率的降低。因此，骨细胞合胞体中产生的单一机械衍生信号可以控制成骨细胞和骨衬细胞功能，从而控制骨生物学中的各种重要现象。 (C) 2000 年，Elsevier Science Inc. 保留所有权利。
A theory is developed to resolve several inconsistencies between current concepts and observations about bone remodeling. For example, the Observation that remodeling increases both when mechanical loading is excessively low, that is, in a disuse state, and when it is excessively high, producing substantial fatigue damage, is contrary to the widely held assumption that a signal generated by osteocytes in proportion to mechanical loading stimulates bone lining cells to activate remodeling. The new theory resolves this disparity by assuming that lining cells are inclined to activate remodeling unless restrained by an inhibitory signal, and that the mechanically provoked osteocytic signal serves this inhibitory function. Consequently, remodeling is elevated when signal generation declines due to reduced loading, or when signal generation or transmission is interrupted by damage due to excessive loading. Otherwise, remodeling is kept at a relatively low level by inhibitory signals produced through physiologic loading. Furthermore, the inhibitory signal is postulated to be identical to that proposed by Marotti as the mechanism for conversion of osteoblasts to osteocytes, and responsible for the diminishment of apposition rate during refilling of osteonal basic multicellular units. Consequently, a single, mechanically derived signal, produced in the osteocytic syncytium, may control osteoblast and bone lining cell functions, and thereby a variety of important phenomena in bone biology. (C) 2000 by Elsevier Science Inc. All rights reserved.