Leka, a New Platelet Antigen Absent in Glanzmann's Thrombasthenia
Leka, a New Platelet Antigen Absent in Glanzmann's Thrombasthenia
复制标题
Leka，一种格兰兹曼血小板无力症中不存在的新血小板抗原
DOI：
10.1111/j.1423-0410.1984.tb00047.x
复制
发表时间：
1984
期刊：
影响因子：
2.7
通讯作者：
J. Wautier
中科院分区：
文献类型：
--
作者：
B. Boizard;J. Wautier
一名出现输血后紫癜症的患者的血清中含有针对一种以前未描述的血小板抗原Leka的抗体。经免疫荧光、~(51)Cr裂解和~(14)C-5-羟色胺释放等方法检测其抗血小板活性。法国人群中Leka表型频率为98.18%。Leka似乎与性别无关，似乎与Baka抗原密切相关。Leka抗原在血小板减少性疾病中不表达，但在Bernard-Soulier综合征患者的血小板上发现，提示该抗原由血小板膜糖蛋白IIb和/或IIIa携带。
The serum of a patient who developed a posttransfusion purpura contained antibodies directed against a previously undescribed platelet antigen Leka. The antiplatelet activity was present in the IgG fraction and was detected by immunofluorescence, 51Cr lysis and 14C‐serotonin release. The frequency of the Leka phenotype in the French population is 98.18%. Leka does not appear to be sex‐linked and seems to be closely related to the Baka antigen. The Leka antigen is not expressed on thrombasthenic platelets but is found on platelets from patients with the Bernard‐Soulier syndrome which suggests that this antigen is carried by platelet glycoproteins IIb and/or IIIa.