Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs.
Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs.
复制标题
在美国猪群中传播的当代 2010.1 H3N2 甲型猪流感病毒的特征。
DOI：
10.1016/j.virol.2020.11.006
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Vincent,AmyL
中科院分区：
文献类型：
--
作者：
Powell,JoshuaD;Abente,EugenioJ;Chang,Jennifer;Souza,CarineK;Rajao,DanielaS;Anderson,TavisK;Zeller,MichaelA;Gauger,PhillipC;Lewis,NicolaS;Vincent,AmyL
2012年，猪流感监测发现了一种新的重组甲型流感病毒（IAV）株，含有人季节性血凝素（HA）和神经氨酸酶（NA）。随后，这些病毒重新组合，仅保留人源H3，这导致新的病毒谱系成为美国猪中最常检测到的H3进化枝（2010.1 HA进化枝）。在这里，我们评估了抗原表型，毒力和传播特性，这种病毒谱系后，其介绍给猪。相对于2012年和2014年的2010.1病毒，2015-2017年的最新2010.1当代毒株在猪中导致等同的肉眼可见肺部病变和传播。先前定义的HA抗原基序内氨基酸残基145处的单个突变与抗原表型的变化相关，可能损害疫苗效力。自2012年以来在猪中传播的当代2010.1病毒与2012年前猪中的H3 N2病毒和人类季节性H3 N2病毒都有显著不同，并证明了该谱系内的持续进化。
In 2012, swine influenza surveillance detected a novel reassorted influenza A virus (IAV) strain containing human-seasonal hemagglutinin (HA) and neuraminidase (NA). Subsequently, these viruses reassorted, maintaining only the human-origin H3, which resulted in a new lineage of viruses that became the most frequently detected H3 clade in US swine (2010.1 HA clade). Here, we assessed the antigenic phenotype, virulence, and transmission characteristics of this virus lineage following its introduction to swine. Relative to 2010.1 viruses from 2012 and 2014, recent 2010.1 contemporary strains from 2015-2017 resulted in equivalent macroscopic lung lesions and transmission in pigs. A single mutation at amino acid residue 145 within the previously defined HA antigenic motif was associated with a change of antigenic phenotype, potentially impairing vaccine efficacy. Contemporary 2010.1 viruses circulating in swine since 2012 were significantly different from both pre-2012 H3N2 in swine and human-seasonal H3N2 viruses, and demonstrated continued evolution within the lineage.