Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients.
Baseline Oxidative Stress Is Associated with Memory Changes in Omega-3 Fatty Acid Treated Coronary Artery Disease Patients.
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DOI：
10.1155/2017/3674371
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Lanctôt KL
中科院分区：
文献类型：
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作者：
Mazereeuw G;Herrmann N;Andreazza AC;Scola G;Ma DWL;Oh PI;Lanctôt KL
本研究调查了治疗前氧化应激（通过脂质过氧化氢 (LPH)、4-羟基-2-壬烯醛 (4-HNE)、8-异前列腺素 (8-ISO) 和丙二醛 (MDA) 测量）是否与 n-3 PUFA 治疗的冠状动脉疾病患者的即时回忆改善相关。 这是 CAROTID 试验 (NCT00981383) 的二次分析。使用加州言语学习测试第二版和简短视觉空间记忆测试修订版测量复合即时回忆。分析空腹血液中的 LPH、4-HNE、8-ISO、MDA 和 n-3 PUFA 浓度。然后患者接受 n-3 PUFA 治疗或安慰剂 12 周，之后重新评估复合即时回忆。使用线性回归来研究每个治疗组中脂质过氧化标记物与复合即时回忆变化之间的关系。 纳入 85 名患者（年龄 = 61.1 ± 8.5，77% 男性，平均受教育年限 = 15.3 ± 3.4）（n = 46 安慰剂，n = 39 n-3 PUFA）。在调整多重比较和潜在混杂因素后，LPH (β = 0.45，p = .002) 和 4-HNE (β = 0.38，p = .005) 基线浓度越高，n-3 PUFA 治疗的患者复合即时回忆能力的改善越大。没有观察到其他关联。 N-3 PUFA 治疗可能更有可能改善氧化应激较高患者的即时回忆。
This study investigated whether pretreatment oxidative stress, measured by lipid hydroperoxides (LPH), 4-hydroxy-2-nonenal (4-HNE), 8-isoprostane (8-ISO), and malondialdehyde (MDA), was associated with improvement in immediate recall among n-3 PUFA-treated coronary artery disease patients. This was a secondary analysis of the CAROTID trial (NCT00981383). Composite immediate recall, measured using the California Verbal Learning Test, Second Edition, and the Brief Visuospatial Memory Test-Revised, was assessed. LPH, 4-HNE, 8-ISO, MDA, and n-3 PUFA concentrations were analysed from fasting blood. Patients then received either n-3 PUFA treatment or placebo for 12 weeks, after which composite immediate recall was reassessed. Linear regression was used to investigate relationships between lipid peroxidation markers and changes in composite immediate recall in each treatment group. Eighty-five patients (age = 61.1 ± 8.5, 77% male, mean years of education = 15.3 ± 3.4) were included (n = 46 placebo, n = 39 n-3 PUFA). After adjusting for multiple comparisons and potential confounders, greater baseline concentrations of LPH (β = 0.45, p = .002) and 4-HNE (β = 0.38, p = .005) were associated with greater improvement in composite immediate recall among n-3 PUFA-treated patients. No other associations were observed. N-3 PUFA treatment may be more likely to improve immediate recall in patients with greater oxidative stress.