Associations between birthweight and weight change during infancy and later childhood, and systolic blood pressure at age 15 years: the COMPASS study
Associations between birthweight and weight change during infancy and later childhood, and systolic blood pressure at age 15 years: the COMPASS study
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DOI：
10.1111/j.1365-3016.2008.01007.x
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发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
Rasmussen, Finn
中科院分区：
文献类型：
--
作者：
Kark, Malin;Tynelius, Per;Rasmussen, Finn
关于产后体重变化与后期血压之间的关系，已有不一致的研究结果。本研究分析了胎儿期、婴儿期和儿童后期体重变化对青春期收缩压（SBP）的影响。在瑞典斯德哥尔摩进行了一项基于人群的纵向研究。从医学出生登记册中提取出生时的体重、身长和胎龄，从儿童健康记录中收集儿童期的体重和身高，并在15岁时的健康检查中测量身体尺寸和SBP。使用线性回归分析了2438例个体的完整数据，在完全校正的模型中，在生命的第一年中，体重每增加1 SD，女孩的SBP增加0.99 mmHg [95%置信区间（CI），0.27，1.71]，男孩的SBP增加1.02 mmHg [0.31，1.73]。从10岁到15岁，体重每增加1 SD，男孩体重变化对SBP的影响为3.70 mmHg [2.67，4.73]，女孩为1.30 mmHg [0.38，2.22]。婴儿期和儿童后期的体重增加与15岁时的SBP呈正相关，而出生体重与SBP呈较弱的负相关。从1岁到10岁没有观察到体重增加的明显影响。婴儿期的体重变化程度对男孩和女孩的SBP同样重要，而青春期的生长与男孩的SBP的关系比女孩的要大。
Inconsistent findings have been reported on associations between postnatal weight change with later blood pressure. This study analysed the impact of weight change during fetal life, infancy and later childhood on systolic blood pressure (SBP) in adolescence. A longitudinal population-based study was conducted in Stockholm, Sweden. Weight, length at birth and gestational age were extracted from the Medical Birth Register, weight and height in childhood was collected from child health records, and body size and SBP were measured during a health examination at 15 years of age. Complete data on 2438 individuals were analysed using linear regression.In fully adjusted models SBP increased 0.99 mmHg [95% confidence interval (CI), 0.27, 1.71] in girls and 1.02 mmHg [0.31, 1.73] in boys per 1 SD increase in weight during the first year of life. The effect on SBP of weight change from 10 to 15 years among boys was 3.70 mmHg [2.67, 4.73] and among girls 1.30 mmHg [0.38, 2.22] per 1 SD increase in weight. Weight gain in infancy and later childhood was positively associated with SBP at age 15 years, while birthweight showed a weaker inverse association with SBP. No apparent effect of weight gain from 1 to 10 years of age was seen. Degree of weight change in infancy was equally important for SBP in both boys and girls, while growth during puberty showed a stronger association with SBP among boys than among girls.