HUMAN-LEUKOCYTE ANTIGEN REGION INVOLVEMENT IN THE GENETIC PREDISPOSITION TO ALOPECIA-AREATA
HUMAN-LEUKOCYTE ANTIGEN REGION INVOLVEMENT IN THE GENETIC PREDISPOSITION TO ALOPECIA-AREATA
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DOI：
10.1159/000248775
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发表时间：
1987-07-01
期刊：
影响因子：
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通讯作者：
RABBIOSI, G
中科院分区：
文献类型：
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作者：
ORECCHIA, G;BELVEDERE, MC;RABBIOSI, G
本文对127例斑秃患者进行了人类白细胞抗原（HLA）Ⅰ类和Ⅱ类的研究。根据（1）脱发区域，（2）性别，（3）发病机制，（4）对局部免疫调节剂（方酸二丁酯和苯环酮）的反应和（5）发病年龄，将患者细分为不同的组。HLA Ⅰ类分子标记（A、B、C位点）频率与对照组无显著差异。然而，在II类抗原（位点DR，DQ），DR 5的频率增加斑秃和普秃时，与对照组相比。特别是，DR 5与早发性形式密切相关。DR 5频率最高（62%）见于早发和最严重形式的疾病患者组（p < 0.01; RR=3.14）。斑秃组HLA-B8表型频率低于普秃组。女性患者与对照组之间无显著差异。然而，在雄性中观察到CW 3增加和DR 1减少。在Ikeda's型脱发中，“混合型”、“高血压前期”、“特应性”脱发组与“普通型”脱发组及对照组比较，HLA-A28、DR 5的频率增高，DR 1的频率降低。不可能发现这些遗传标记与局部免疫调节剂的反应之间的任何关系。
Human leukocyte antigens (HLA) of classes I and II were studied in 127 patients with alopecia areata (AA). The patients were subdivided into different groups depending on (1) hair loss area, (2) sex, (3) pathogenesis, (4) response to topical immune modulators (squaric acid dibutylester and diphencyprone) and (5) age of onst of the disease. The frequencies of class I HLA markers (loci A, B, C) were not significantly different from the controls. However, among the class II antigens (loci DR, DQ), the frequency of DR5 was increased in both alopecia areata and alopecia universalis when compared with the control group. In particular, DR5 was strongly linked to the early-onset form. The highest DR5 frequency (62%) was found in the group of patients which presented both the early onset and the most severe form of the disease (p < 0.01; RR=3.14). A decrease of the HLA-B8 phenotype frequency was found in the alopecia areata group versus the alopecia universalis one. No significant deviation was found between the female patients and the control group. However, an increase of CW3 and a decrease of DR1 was seen in the males. In the group including ''combined'', ''prehypertensive, ''atopic'' alopecia of Ikeda''s classification the frequency of HLA-A28 and DR5 was increased and that of DR1 was decreased in comparison with the ''common'' type of alopecia and the controls. It was not possible to find any relationship between these genetic markers and the response to topical immune modulators.