Cerumen phenotype and epithelial dysplasia in nipple aspirates of breast fluid.
Cerumen phenotype and epithelial dysplasia in nipple aspirates of breast fluid.
复制标题
乳腺液体的乳头抽吸物中的耵聍表型和上皮发育不良。
DOI：
10.1002/ajpa.1330620115
复制
发表时间：
1983
影响因子：
2.8
通讯作者：
Petrakis,NL
中科院分区：
文献类型：
--
作者：
Petrakis,NL
在1150名白人和亚裔美国妇女中，研究了乳头吸出液中异型上皮细胞的存在与湿型或干型之间的关系。与干型颈型相比，绝经前表现为湿型颈型的白人妇女的细胞学异常增殖率显著高于干型(相对危险度6.5[1.8-22.3])。这种影响在绝经后妇女中没有观察到。这一发现为我们的假说提供了新的支持，即影响乳腺分泌的顶分泌遗传因素可能会影响乳房上皮对外源性或内源性潜在致癌物质的暴露。
The relationship between presence of dysplastic epithelial cells in nipple aspirates of breast fluid and wet or dry cerumen phenotype was studied in 1,150 white and Asian American women. A statistically significant greater proportion of premenopausal white women of wet cerumen phenotype, compared to women of the dry cerumen type, was found to have cytologic dysplasia (relative risk 6.5 [1.8–22.3]). The effect was not observed in postmenopausal women. The finding offers new support for our hypothesis that an apocrine genetic factor affecting breast gland secretion may influence exposure of the breast epithelium to potential carcinogenic substances of exogenous or endogenous origin.