Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring
Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring
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DOI：
10.1079/bjn2003881
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发表时间：
2003-07-01
影响因子：
3.6
通讯作者：
Forhead, AJ
中科院分区：
文献类型：
--
作者：
Lisle, SJM;Lewis, RM;Forhead, AJ
在大鼠中，怀孕期间的母体贫血会导致成年后代高血压，尽管其机制尚不清楚。本研究调查了怀孕期间缺铁母亲所生成年大鼠的肾脏形态。在交配前1周至整个妊娠期间，分别饲喂对照组（153 mg/kg饲粮，n 7）和低铁组（3 mg/kg饲粮，n 6）。在分娩时，铁限制（IR）的母亲贫血；IR幼崽在2日龄时也出现贫血和生长迟缓。在3个月和16个月时，IR后代的收缩压（分别为163 （SEM 4）和151 (SEM 4) mmHg, n 13）高于对照动物(分别为145 （SEM 3）和119 (SEM 4) mmHg, n 15， P
In rats, maternal anaemia during pregnancy causes hypertension in the adult offspring, although the mechanism is unknown. The present study investigated the renal morphology of adult rats born to mothers who were Fe-deficient during pregnancy. Rats were fed either a control (153 mg Fe/kg diet, n 7) or low-Fe (3 mg/kg diet, n 6) diet from 1 week before mating and throughout gestation. At delivery, the Fe-restricted (IR) mothers were anaemic; the IR pups were also anaemic and growth-retarded at 2 d of age. At 3 and 16 months, systolic blood pressure in the IR offspring (163 (SEM 4) and 151 (SEM 4) mmHg respectively, n 13) was greater than in control animals (145 (SEM 3) and 119 (SEM 4) mmHg respectively, n 15, P