Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T-1 Magnetic Resonance Imaging Contrast Agent
Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T-1 Magnetic Resonance Imaging Contrast Agent
复制标题
动态同步热分解合成超小型铁氧体纳米粒子用于高性能多功能T-1磁共振成像造影剂
DOI：
10.1021/acsnano.6b07684
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发表时间：
2017
期刊：
影响因子：
17.1
通讯作者：
Fan HM
中科院分区：
文献类型：
--
作者：
Zhang Huan;Li Li;Liu Xiao Li;Luo Yan E.;Peng Ming Li;Jiao Ju;Ng Cheng-Teng;Bay Boon-Huat;Yi Jia Bao;Zhao Ling Yun;Gu Ning;Fan HM
大规模合成单分散超小金属铁氧体纳米颗粒以及了解化学成分和MR信号增强之间的相关性对于开发下一代超灵敏T1磁共振成像（MRI）纳米探针至关重要。本文以超小MnFe 2 O 4纳米粒子（UMFNPs）为模型体系，采用动态同时热分解（DSTD）方法可控合成了粒径小于4 nm的单分散超小金属铁氧体纳米粒子。比较研究表明，使用与金属油酸盐前体配对的芥酸铁的DSTD实现了成核掺杂过程，这对于超小金属铁氧体纳米颗粒的粒度和分布控制至关重要。DSTD法合成NiFe 2 O 4和CoFe 2 O 4纳米粒子的实验结果进一步证实了DSTD法的原理。更重要的是，DSTD合成的成功使我们能够通过调整磁性氧化铁纳米探针的化学组成来调整其MR和生物化学性质。得益于Mn 2+掺杂剂，合成的UMFNPs在迄今报道的具有相似尺寸的铁氧体纳米颗粒中表现出最高的弛豫率（高达8.43 mM-1 s-1），并证明了一种多功能的T1 MR纳米探针，可同时用于体内高分辨率血池和肝脏特异性MRI。我们的研究提供了一个通用的策略来合成超小的多组分磁性纳米粒子，这提供了一个高灵敏度的超小磁性纳米粒子basedT 1 MRI探针的各种临床诊断应用的化学设计的可能性。
Large-scale synthesis of monodisperse ultrasmall metal ferrite nanoparticles as well as understanding the correlations between chemical composition and MR signal enhancement is critical for developing next-generation, ultrasensitiveT1magnetic resonance imaging (MRI) nanoprobes. Herein, taking ultrasmall MnFe2O4nanoparticles (UMFNPs) as a model system, we report a general dynamic simultaneous thermal decomposition (DSTD) strategy for controllable synthesis of monodisperse ultrasmall metal ferrite nanoparticles with sizes smaller than 4 nm. The comparison study revealed that the DSTD using the iron-eruciate paired with a metal-oleate precursor enabled a nucleation-doping process, which is crucial for particle size and distribution control of ultrasmall metal ferrite nanoparticles. The principle of DSTD synthesis has been further confirmed by synthesizing NiFe2O4and CoFe2O4nanoparticles with well-controlled sizes of ∼3 nm. More significantly, the success in DSTD synthesis allows us to tune both MR and biochemical properties of magnetic iron oxide nanoprobes by adjusting their chemical composition. Beneficial from the Mn2+dopant, the synthesized UMFNPs exhibited the highestr1relaxivity (up to 8.43 mM–1s–1) among the ferrite nanoparticles with similar sizes reported so far and demonstrated a multifunctionalT1MR nanoprobe forin vivohigh-resolution blood pool and liver-specific MRI simultaneously. Our study provides a general strategy to synthesize ultrasmall multicomponent magnetic nanoparticles, which offers possibilities for the chemical design of a highly sensitive ultrasmall magnetic nanoparticle basedT1MRI probe for various clinical diagnosis applications.