COMBINED IMMUNODEFICIENCY PRECEDING CHRONIC LYMPHOCYTIC-LEUKEMIA
COMBINED IMMUNODEFICIENCY PRECEDING CHRONIC LYMPHOCYTIC-LEUKEMIA
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DOI：
10.1007/bf00320340
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
HAANEN, C
中科院分区：
文献类型：
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作者：
LENDERS, JWM;DEPAUW, BE;HAANEN, C
一名66岁女性，患有反复呼吸道感染，出现严重的低丙种球蛋白血症和细胞介导的免疫功能受损，并伴有腹部淋巴结病和脾肿大。考虑到淋巴恶性肿瘤，进行了剖腹探查术。无法确定恶性肿瘤。随访2年后，可诊断为慢性淋巴细胞白血病。在慢性淋巴细胞白血病发生前2年出现低丙种球蛋白血症的文献尚未报道。
A 66 yr old female, suffering from recurrent infections of the respiratory tract, developed a severe hypogammaglobulinemia and an impaired cell mediated immunity in combination with abdominal lymphadenopathy and splenomegaly. Considering a lymphoid malignancy, an explorative laparotomy was performed. No malignancy could be established. After a follow-up of 2 yr a diagnosis of chronic lymphocytic leukemia could be made. The onset of hypogammaglobulinemia 2 yr before the development of chronic lymphocytic leukemia is not yet reported in the literature.