Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects
Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects
复制标题
DOI：
10.1097/01.blo.0000164298.63534.64
复制
发表时间：
2005-07-01
影响因子：
4.2
通讯作者：
Erggelet, C
中科院分区：
文献类型：
--
作者：
Browne, JE;Anderson, AF;Erggelet, C
Peterson在自体软骨细胞植入的首次临床应用方面的开创性经验表明，对于困难患者群体，临床结局得到了改善，持续时间长达11年。对该技术在美国的普遍适用性的评估需要长期的多中心随访。这项多中心队列研究的目的是评估自体软骨细胞植入治疗股骨远端病变的患者的临床结局。使用改良的辛辛那提膝关节评分系统的10分量表测量基线和5年时的结局评估。87%（87/100）的患者完成了5年随访评估。患者平均年龄为37岁，平均总缺损尺寸为4.9 cm（2），基线总体状况评分较低。70%的患者至少有一次软骨修复手术失败。随访时，87例患者报告总体状况评分平均改善2.6分，其中62例病情改善，6例病情无变化，19例病情恶化。在改善的62例患者中，随访时平均总体状况评分改善4.1分。自体软骨细胞植入治疗股骨远端大软骨缺损的患者报告在5年随访时结局评分改善。
Peterson's pioneering experience with the first clinical application of autologous chondrocyte implantation showed improvement in clinical outcomes, durable as much as 11 years, for a difficult patient population. An assessment of the general applicability of this technology in the United States requires long-term, multicenter followup. The purpose of this multicenter cohort study was to assess the clinical outcomes of patients treated with autologous chondrocyte implantation for lesions of the distal femur. Modified 10-point scales of the Cincinnati knee rating system were used to measure outcomes assessments at baseline and at 5 years. Eighty-seven percent (87 of 100) of patients completed 5-year followup assessments. Patients were an average 37 years of age, had a mean total defect size of 4.9 cm(2), and had low baseline overall condition scores. At least one prior cartilage repair procedure had failed in 70% of the patients. At followup, 87 patients reported a mean improvement of 2.6 points in the overall condition score, including 62 with improved conditions, six with no change in condition, and 19 with worsened conditions. Of the 62 patients who improved, the mean over-all condition score improved 4.1 points at followup. Patients treated with autologous chondrocyte implantation for large cartilage defects in the distal femur reported improvement in outcome scores at 5 years followup.