The increased interleukin-13 in patients with systemic lupus erythematosus: Relations to other Th1-, Th2-related cytokines and clinical findings
The increased interleukin-13 in patients with systemic lupus erythematosus: Relations to other Th1-, Th2-related cytokines and clinical findings
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DOI：
10.3109/08916930108994122
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Hashimoto, H
中科院分区：
文献类型：
--
作者：
Morimoto, S;Tokano, Y;Hashimoto, H
检测系统性红斑狼疮（SLE）患者血清白细胞介素13（IL-13）水平，并与其他Th 1/Th 2相关细胞因子、临床表现及其他指标进行相关性分析。采用酶联免疫吸附试验（ELISA）检测血清IL-13、细胞因子、可溶性标志物水平。活动期SLE患者IL-13水平显著升高。大多数IL-13水平高的患者IL-6水平也较高，部分患者γ IFN水平也较高。根据这些增加的细胞因子的模式将这些患者分为两组;一组仅具有高水平的Th 2相关细胞因子（IL-13或IL-6），另一组具有高水平的Th 2相关和Th 1相关细胞因子（γ IFN或IL-2）。后者患者可溶性CD 8和CD 23水平高，部分患者有溶血性贫血或肺部受累，而前者患者大多数有肾病。因此，在SLE中，IL-13水平升高，并且升高的Th 2和Th 1相关细胞因子的异质性与活化标志物和临床表现的异质性相关。
The levels of interleukin-13 (IL-13) in patients with systemic lupus erythematosus (SLE) were examined and related to other Th1-/Th2- related cytokines, clinical manifestations and other markers. Serum levels of IL-13 and other cytokines, soluble markers were measured by enzyme-linked immunosorbent assay (ELISA). Patients with active SLE had a significantly increased level of IL-13. Most patients with high levels of IL-13 had higher levels of IL-6, and some patients had high levels of gamma IFN. These patients were divided into two groups according to the patterns of these increased cytokines; one with a high level of only Th2 related cytokines (IL-13 or IL-6) and another with high levels of both Th2 related and Th1 related cytokines (gamma IFN or IL-2). The latter patients had high levels of soluble CD8 and CD23, and some of them had hemolytic anemia or pulmonary involvement, while most of the former patients had nephropathy. Thus, in SLE, the levels of IL-13 were increased, and the heterogeneity of increased Th2- and Th1-related cytokines was related to that of activation markers and clinical manifestations.