Impaired trace fear conditioning following neonatal ethanol: reversal by choline.
Impaired trace fear conditioning following neonatal ethanol: reversal by choline.
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DOI：
10.1037/0735-7044.120.2.482
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发表时间：
2006-04
影响因子：
1.9
通讯作者：
A. Wagner;P. Hunt
中科院分区：
文献类型：
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作者：
A. Wagner;P. Hunt
新生儿乙醇暴露会导致动物在海马体依赖性空间记忆测试中的表现缺陷，最近的研究表明，额外的饮食胆碱可以改善这些缺陷。在本实验中，大鼠在产后4-9天每天给予5.25 g/kg ig乙醇或假插管，并在PD 4-20天皮下注射胆碱（18.8 mg/ml溶液0.1 ml）或生理盐水。在PD 30时，给予大鼠延迟或痕量恐惧条件反射试验，并在24小时后进行条件刺激诱导冻结试验。新生儿乙醇在微量条件作用中产生了深刻的损害，这种损害被胆碱逆转。各组在延迟条件反应方面没有差异，表明新生儿乙醇产生相对选择性的认知缺陷，可以通过补充胆碱来缓解。
Neonatal ethanol exposure in animals results in performance deficits on tests of hippocampus-dependent spatial memory, and recent studies have shown that extra dietary choline can ameliorate some of these impairments. In this experiment, rats were administered 5.25 g/kg ig ethanol per day or sham intubations on Postnatal Days (PD) 4-9 and choline (0.1 ml of an 18.8 mg/ml solution) or saline subcutaneously on PD 4-20. On PD 30, rats were given delay or trace fear conditioning trials and were tested for conditioned stimulus-elicited freezing 24 hr later. Neonatal ethanol produced a profound impairment in trace conditioning that was reversed by choline. Groups did not differ in delay conditioned responding, indicating that neonatal ethanol produces a relatively selective cognitive deficit that can be alleviated with supplemental choline.