Sulcal depth in prefrontal cortex: a novel predictor of working memory performance
Sulcal depth in prefrontal cortex: a novel predictor of working memory performance
复制标题
前额皮质脑沟深度：工作记忆性能的新预测因子
DOI：
10.1093/cercor/bhac173
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Weiner, Kevin S.
中科院分区：
文献类型：
--
作者：
Yao, Jewelia K.;Voorhies, Willa I.;Miller, Jacob A.;Bunge, Silvia A.;Weiner, Kevin S.
支持认知发展的神经解剖学变化是神经科学的主要兴趣所在。在需要考虑的神经解剖学的许多方面中，第三脑沟特别有吸引力，因为它们在妊娠最后出现，在出生后显示出长期的发育，并且是人类或类人猿特异性的。因此，它们是探索形态认知与认知技能之间关系的理想目标，这些认知技能也表现出长期的发展，例如工作记忆（WM）。然而，脑沟形态与 WM 之间的关系尚不清楚——无论是在发育过程中还是更普遍的情况下。为了填补这一空白，我们采用了数据驱动的交叉验证方法，研究了 60 名 6 至 18 岁儿童和青少年的外侧前额叶皮层 (LPFC) 沟深度与言语 WM 之间的关系。这些分析确定了 9 名左侧 LPFC 沟，没有右侧 LPFC 沟（其中 7 名是三级沟），其深度预测言语 WM 表现超出了年龄的影响。大多数脑沟位于先前提出的 LPFC 功能分区的轮廓内和周围。该脑沟深度模型优于年龄或皮质厚度模型。总之，这些发现为经典理论提供了实证支持，即第三脑沟是关联皮质的标志，有助于晚熟的人类认知能力。
The neuroanatomical changes that underpin cognitive development are of major interest in neuroscience. Of the many aspects of neuroanatomy to consider, tertiary sulci are particularly attractive as they emerge last in gestation, show a protracted development after birth, and are either human- or hominoid-specific. Thus, they are ideal targets for exploring morphological-cognitive relationships with cognitive skills that also show protracted development such as working memory (WM). Yet, the relationship between sulcal morphology and WM is unknown—either in development or more generally. To fill this gap, we adopted a data-driven approach with cross-validation to examine the relationship between sulcal depth in lateral prefrontal cortex (LPFC) and verbal WM in 60 children and adolescents between ages 6 and 18. These analyses identified 9 left, and no right, LPFC sulci (of which 7 were tertiary) whose depth predicted verbal WM performance above and beyond the effect of age. Most of these sulci are located within and around contours of previously proposed functional parcellations of LPFC. This sulcal depth model outperformed models with age or cortical thickness. Together, these findings build empirical support for a classic theory that tertiary sulci serve as landmarks in association cortices that contribute to late-maturing human cognitive abilities.