Short periods of darkness fail to restore visual or neural plasticity in adult cats
Short periods of darkness fail to restore visual or neural plasticity in adult cats
复制标题
DOI：
10.1017/s0952523817000335
复制
发表时间：
2018-01-31
影响因子：
1.9
通讯作者：
Mitchell, Donald E.
中科院分区：
文献类型：
--
作者：
Holman, Kaitlyn D.;Duffy, Kevin R.;Mitchell, Donald E.
研究表明，即使在 14 周龄时，小猫早期单眼剥夺 (MD) 后的视力丧失在 10 天完全黑暗后也能迅速缓解。为了检验 10 天的黑暗是否对任何年龄的人都有好处，我们测量了成年猫在黑暗后被剥夺的眼睛的视力恢复程度，这些成年猫接受了与之前对小猫进行的实验相同的早期 MD 期。对不同动物进行的平行研究检查了黑暗改变MD诱导的细胞体大小层状差异的程度以及背外侧膝状体核（dLGN）中神经丝（NF）蛋白的免疫反应性的程度。结果表明，一岁时施加 10 天的黑暗既不能减轻早期 MD 引起的失明眼的敏锐度损失，也不能减少 dLGN 中体细胞大小的同时层差异或 NF 损失。
It has been shown that the visual acuity loss experienced by the deprived eye of kittens following an early period of monocular deprivation (MD) can be alleviated rapidly following 10 days of complete darkness when imposed even as late as 14 weeks of age. To examine whether 10 days of darkness conferred benefits at any age, we measured the extent of recovery of the visual acuity of the deprived eye following the darkness imposed on adult cats that had received the same early period of MD as used in prior experiments conducted on kittens. Parallel studies conducted on different animals examined the extent to which darkness changed the magnitude of the MD-induced laminar differences of the cell soma size and immunoreactivity for the neurofilament (NF) protein in the dorsal lateral geniculate nucleus (dLGN). The results indicated that 10 days of darkness imposed at one year of age neither alleviated the acuity loss of the deprived eye induced by an earlier period of MD nor did it decrease the concurrent lamina differences of the soma size or NF loss in the dLGN.