Minimally-Invasive and Non-Invasive Continuous Glucose Monitoring Systems: Indications, Advantages, Limitations and Clinical Aspects
Minimally-Invasive and Non-Invasive Continuous Glucose Monitoring Systems: Indications, Advantages, Limitations and Clinical Aspects
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DOI：
10.2174/157339908785294415
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Van Gaal, Luc
中科院分区：
文献类型：
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作者：
De Block, Christophe;Vertommen, Jan;Van Gaal, Luc
在（接近）连续的基础上感测葡萄糖的准确且可靠的设备可以促进需要进行的特定治疗调整以避免低血糖和高血糖偏移，从而改善代谢控制。当前的连续葡萄糖监测（CGM）系统指示葡萄糖水平、葡萄糖水平变化的方向和幅度，并且可用于评估血糖变异性。此外，实时CGM传感器可用作预测即将发生的血糖波动的工具，从而提供低血糖和高血糖值的警报信号，警告患者采取预防措施。使用CGM还可以通过减少对低血糖的恐惧来改善生活质量。特别是脆性糖尿病患者、低血糖无意识、胃轻瘫、孕妇或泵使用者，他们有动力参与糖尿病护理并且技术熟练，可以从CGM中受益。然而，为了在日常实践中成功实施CGM，这些设备必须准确可靠，并且必须意识到当前CGM系统的局限性，这些局限性源于生理和技术方面。CGM能否成功改善代谢控制、减少低血糖发作和改善大多数患者的生活质量仍有待证实。如果是这样的话，实时CGM可以减少慢性糖尿病并发症，并避免住院，从而降低health care costs.In这篇文章中，我们将审查当前minimallyinvasive和non-invasive CGM传感器的适应症，优势，局限性，临床和技术方面。
Accurate and reliable devices sensing glucose on a (near)-continuous basis may facilitate specific therapeutic adjustments that need to be made to avoid hypo-and hyperglycaemic excursions, thereby improving metabolic control. Current continuous glucose monitoring (CGM) systems indicate the glucose level, the direction and magnitude of change of glucose levels, and can be used to assess glycaemic variability. In addition, real-time CGM sensors can serve as a tool to predict impending glucose excursions, thereby providing alarm signals of hypo-and hyperglycaemic values warning the patient to take preventative actions. Quality of life may also improve by using CGM via reducing the fear of hypoglycaemia.Particularly patients with brittle diabetes, hypoglycaemia unawareness, gastroparesis, pregnant women, or pump users, who are motivated to participate in their diabetes care and are technologically adept, may benefit from CGM. However, to successfully implement CGM in daily practice, these devices must be accurate and reliable, and one must be aware of the limitations of current CGM systems, that originate from physiological and technical aspects. Whether CGM succeeds in improving metabolic control, reducing hypoglycaemic episodes, and improving quality of life in the majority of patients remains to be proven. Should this be the case, real-time CGM may reduce chronic diabetic complications, and avoid hospitalisations, thereby reducing health care costs.In this article we will review indications, advantages, limitations, clinical and technical aspects of current minimallyinvasive and non-invasive CGM sensors.