Functional long non-coding RNAs in hepatocellular carcinoma
Functional long non-coding RNAs in hepatocellular carcinoma
复制标题
肝细胞癌中的功能性长非编码RNA
DOI：
10.1016/j.canlet.2020.10.042
复制
发表时间：
2021-01-11
期刊：
影响因子：
9.7
通讯作者：
Yang, Jin-E
中科院分区：
文献类型：
--
作者：
Xie, Chen;Li, Song-Yang;Yang, Jin-E
肝细胞癌（HCC）是一种常见的恶性肿瘤，在世界范围内发病率很高。肝癌的发生是一个复杂的多步骤过程，其潜在的分子机制仍然很大程度上未知。近年来，长链非编码RNA（lncRNA）作为一类新发现的分子，在肝癌的发生发展中起着重要的调节作用。HCC相关lncRNA通过调节基因表达或蛋白活性影响多种恶性表型。此外，肝脏中lncRNA的失调也与易患HCC的疾病相关，如慢性病毒感染、非酒精性脂肪性肝炎和肝纤维化/肝硬化。对肝癌发展多步骤过程中lncRNA调控网络的深入了解将为肝癌的诊断和治疗提供新的见解。本文介绍了lncRNA的生物学起源和功能，并对lncRNA如何调控HCC的恶性标志，如细胞增殖失控、细胞死亡抵抗、代谢重编程、免疫逃逸、血管生成和转移等方面的最新研究进展进行了综述。我们还回顾了lncRNA在HCC相关肝病中作用的新见解。最后，我们讨论了lncRNA作为早期诊断生物标志物和治疗靶点的潜在应用。
Hepatocellular carcinoma (HCC) is a prevalent human malignancy with high morbidity worldwide. Hepatocarcinogenesis is a complex multistep process, and its underlying molecular mechanisms remain largely unknown. Recently, long non-coding RNAs (lncRNAs), a class of newly discovered molecules, have been revealed as essential regulators in the development of HCC. HCC-associated lncRNAs affect multiple malignant phenotypes by modulating gene expression or protein activity. Moreover, the dysregulation of lncRNAs in the liver is also associated with diseases predisposing to HCC, such as chronic viral infection, nonalcoholic steatohepatitis, and liver fibrosis/cirrhosis. A deeper understanding of the lncRNA regulatory network in the multistep processes of HCC development will provide new insights into the diagnosis and treatment of HCC. In this review, we introduce the biogenesis and function of lncRNAs and summarize recent knowledge on how lncRNAs regulate the malignant hallmarks of HCC, such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis, and metastasis. We also review emerging insights into the role of lncRNAs in HCC-associated liver diseases. Finally, we discuss the potential applications of lncRNAs as early diagnostic biomarkers and therapeutic targets.