Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques
Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques
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DOI：
10.1016/s0015-0282(97)81872-9
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发表时间：
1997-01-01
影响因子：
6.7
通讯作者：
Clarkson, TB
中科院分区：
文献类型：
--
作者：
Honore, EK;Williams, JK;Clarkson, TB
目的：研究大豆植物雌激素对动脉粥样硬化雄性和雌性恒河猴冠状动脉血管反应性的影响。设计：前瞻性、随机、盲法、对照研究。设置：学术医学中心的比较医学临床研究中心。患者：22只预先存在饮食诱导动脉粥样硬化的年轻成年恒河猴。干预：猴子被喂食以大豆为基础的饮食6个月，组成相同，除了从一个（低胆固醇）和完整的另一个（高胆固醇）中提取的胆固醇酮。在研究结束时进行定量冠状动脉造影。低胆固醇组中的女性进行了第二次血管造影后，急性IV剂量的genistein.Main Outcome Measure（S）：近端左回旋支冠状动脉直径的百分比变化，在响应于冠状动脉内乙酰胆碱和硝酸甘油，与对照diameter. Results（S）：动脉收缩的男性在响应于乙酰胆碱。低血压组雌性动物的动脉收缩（-6.2% +/-2.8%，平均值+/- SEM），而高血压组雌性动物的动脉扩张（6.4 +/-1.2%，平均值+/- SEM）。静脉注射染料木黄酮可使先前收缩的低血压雌性动物扩张（3.3 +/- +/- 2.8%）。结论：与哺乳动物雌激素一样，膳食大豆异黄酮可增强雌猴动脉粥样硬化动脉对乙酰胆碱的扩张反应。
Objective: To examine the effects of soy phytoestrogens on coronary vascular reactivity in atherosclerotic male and female rhesus monkeys.Design: A prospective, randomized, blinded, controlled study.Setting: Comparative Medicine Clinical Research Center of an academic medical center.Patient(s): Twenty-two young adult rhesus monkeys with pre-existing diet-induced atherosclerosis.Intervention(s): Monkeys were fed soy-based diets for 6 months identical in composition, except that the isoflavones were extracted from one (low-isoflavone) and intact in the other (high-isoflavone). Quantitative coronary angiography was performed at the end of the study, period. Females in the low-isoflavone group underwent a second angiography after an acute IV dose of genistein.Main Outcome Measure(s): Percent change in diameter of the proximal left circumflex coronary artery in response to intracoronary acetylcholine and nitroglycerin, compared with control diameter.Result(s): Arteries from males constricted in response to acetylcholine. Arteries from females in the low-isoflavone group constricted (-6.2% +/- 2.8%, mean +/- SEM), whereas arteries from females in the high-isoflavone group dilated (6.4 +/- 1.2%, mean +/- SEM). Intravenous administration of genistein caused dilation in the previously constricting low-isoflavone females (3.3 +/- +/- 2.8%).Conclusion(s): Like mammalian estrogens, dietary soy isoflavones enhance the dilator response to acetylcholine of atherosclerotic arteries in female monkeys.