Neurophysiological indices of language impairment in children.
Neurophysiological indices of language impairment in children.
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儿童语言障碍的神经生理学指标。
DOI：
10.1080/000164801300043929
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发表时间：
2001
影响因子：
1.4
通讯作者：
Ruben,RJ
中科院分区：
文献类型：
--
作者：
Shafer,VL;Schwartz,RG;Mor,ML;Kessler,KL;Kurtzberg,D;Ruben,RJ
最近的研究发现，特殊语言障碍（SLI）儿童的大脑外侧裂周皮质存在异常的解剖不对称性。这些研究认为，这种异常的解剖不对称性与SLI儿童的语言障碍有关。到目前为止，还没有研究探讨是否偏离功能不对称的基础上处理的口语在这些儿童。在目前的研究中，SLI儿童在听口头呈现的故事和两种不同的无意义背景时，从31个头皮部位记录了脑电活动。在这些情况下，电活动被时间锁定在语法单词“the”上。SLI儿童在200 ms到400 ms的时间内，在所有的语境中，与对照儿童相比，在处理“the”时表现出反向的不对称性。更具体地说，他们在左颞头皮部位（T7）表现出压抑的处理，在右颞部位（T8）表现出增强的处理。计算电压活动的二阶空间导数（拉普拉斯算子），以去除恒定电压电位和头皮上电压电位的均匀变化。拉普拉斯分析表明，在颞电极部位T7和T8处看到的正电活动的来源是颞叶皮层的侧面。电压电位和拉普拉斯算子的头皮地形图的比较也表明，SLI儿童缺乏一些来自深层神经发生器的贡献，可能在海马或基底神经节。这项调查是第一次证明SLI儿童的异常神经生理不对称性和口语处理之间的直接联系。
Recent investigations of children with specific language impairment (SLI) have found deviant anatomical asymmetry of the perisylvian cortex. These studies argue that this deviant anatomical asymmetry is linked to the language disorders of SLI children. To date no studies have examined whether deviant functional asymmetry underlies the processing of spoken language in these children. In the current study, brain-electrical activity was recorded from 31 scalp sites while children with SLI listened to auditorally presented stories and two different nonsense contexts. Electrical activity was time-locked to the grammatical word ''the'' in these contexts. The SLI children showed reversed asymmetry compared to control children from 200 ms to 400 ms in processing ''the'' in all contexts. More specifically, they showed depressed processing at the left temporal scalp site (T7) and enhanced processing at the right temporal site (T8). The second spatial derivative (the Laplacian) of the voltage activity was calculated to remove constant voltage potential and uniform changes in voltage potential across the scalp. The Laplacian analysis indicated that the sources of the positive electrical activity seen at the temporal electrode sites T7 and T8 are the lateral surfaces of the temporal cortices. A comparison of the scalp topography of the voltage potentials and Laplacian also suggests that children with SLI lack some contribution from a deep neural generator, possibly in the hippocampus or basal ganglia. This investigation is the first to demonstrate a direct link between deviant neurophysiological asymmetry and the processing of spoken language in children with SLI.
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发育性失语症：短元音和延长塞音的感知
影响因子：
2.6
作者：
P. Tallal;M. Piercy
通讯作者：
M. Piercy
DOI：
10.1016/0013-4694(94)90112-0
发表时间：
1994
期刊：
Electroencephalography and clinical neurophysiology
影响因子：
--
作者：
P. Nunez;R. Silberstein;P. Cadusch;R. Wijesinghe;A. Westdorp;R. Srinivasan
通讯作者：
P. Nunez;R. Silberstein;P. Cadusch;R. Wijesinghe;A. Westdorp;R. Srinivasan
严重语言障碍儿童听觉诱发皮层电位的地形图。
DOI：
10.1016/s0165-5876(97)81320-1
发表时间：
1996
期刊：
Scandinavian audiology. Supplementum
影响因子：
--
作者：
I. Tonnquist
通讯作者：
I. Tonnquist
影响因子：
4.6
作者：
PERRIN, F;BERTRAND, O;PERNIER, J
通讯作者：
PERNIER, J