Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women
Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women
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DOI：
10.1210/jc.2015-2913
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发表时间：
2016-01-01
影响因子：
5.8
通讯作者：
Polotsky, Alex J.
中科院分区：
文献类型：
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作者：
Al-Safi, Zain A.;Liu, Huayu;Polotsky, Alex J.
内容：饮食中的ω-3脂肪酸延缓小鼠卵巢衰老并提高卵母细胞质量。目的：测试饮食中补充ω-3多不饱和脂肪酸（PUFA）是否调节育龄妇女的生殖激素。设计：前瞻性干预研究。设置：学术中心。参与者：15名肥胖和12名正常体重（NW）的月经来潮妇女，年龄28-34岁。干预：在每天补充4g二十碳五烯酸和二十二碳六烯酸的omega-3多不饱和脂肪酸1个月之前和之后进行两次频繁的血液采样研究。主要结果指标：血清LH和FSH（基础和GnRH刺激后）。治疗后，两组血浆和红细胞成分中omega-6与omega-3 PUFA的比例均显著降低（均P <0.01）。补充Omega-3 PUFA导致NW但非肥胖女性的FSH和FSH对GnRH的反应平均降低17%（分别为P = .06和P = .03）。补充omega-3多不饱和脂肪酸后，肥胖妇女的血清IL-1 β和TNF-α水平降低（IL-1 β为-72%; TNF-α为-56%;两者均P <0.05），但NW妇女没有。然而，这种减少与肥胖women.Conclusions的激素变化无关：饮食管理与omega-3 PUFA降低血清FSH水平在NW，但不是在卵巢储备正常的肥胖妇女。这种效果是有趣的，并且与小鼠数据一致，即较高的饮食omega-3 PUFA延长生殖寿命。我们的研究结果表明，这种营养干预应该在卵巢储备减少的妇女中进行测试，以延缓卵巢衰老。
Context: Dietary omega-3 fatty acids delay ovarian aging and promote oocyte quality in mice.Objective: To test whether dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA) modulates reproductive hormones in reproductive-age women.Design: Prospective interventional study.Setting: Academic center.Participants: Fifteen obese and 12 normal-weight (NW) eumenorrheic women, ages 28-34 years.Intervention: Two frequent blood-sampling studies were performed before and after 1 month of omega-3 PUFA supplementation with 4g of eicosapentaenoic acid and docosahexaenoic acid daily.Main Outcome Measures: Serum LH and FSH (basal and after GnRH stimulation).Results: The ratio of omega-6 to omega-3 PUFA was significantly reduced in plasma and red blood cell components for both groups after treatment (both P < .01). Omega-3 PUFA supplementation resulted in reduction of FSH and FSH response to GnRH by 17% on average (P = .06 and P = .03, respectively) in NW but not obese women. Serum levels of IL-1 beta and TNF-alpha were reduced after omega-3 PUFA supplementation (-72% for IL-1 beta; -56% for TNF-alpha; both, P < .05) in obese but not in NW women. This reduction, however, was not associated with a hormonal change in obese women.Conclusions: Dietary administration with omega-3 PUFA decreased serum FSH levels in NW but not in obese women with normal ovarian reserve. This effect is intriguing and is directionally consistent with murine data whereby higher dietary omega-3 PUFA extends reproductive lifespan. Our results imply that this nutritional intervention should be tested in women with diminished ovarian reserve in an attempt to delay ovarian aging.