Lifespan changes in motor activation and inhibition during choice reactions: A Laplacian ERP study
Lifespan changes in motor activation and inhibition during choice reactions: A Laplacian ERP study
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DOI：
10.1016/j.biopsycho.2011.11.005
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发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
van der Molen, Maurits W.
中科院分区：
文献类型：
--
作者：
de Laar, Maria C. van;van den Wildenberg, Wery P. M.;van der Molen, Maurits W.
反应速度从童年到成年早期都在提高，随着年龄的增长而稳步下降。本研究采用选择反应时（RI）任务，探讨了初级运动皮层（M1）对反应速度和准确性寿命变化的贡献。两组儿童（8岁和12岁）和两组成人（21岁和76岁）对左箭头或右箭头做出了反应。RTs显示出典型的U型寿命模式。RT通过使用中央运动命令的开始（即，LRP和负拉普拉斯电位）和反应相关EMG的开始。运动前时间对年龄变化最为敏感。此外，积极的拉普拉斯电位，假设与抑制不正确的反应选择，是不存在的儿童。在成年人中，同侧阳性的发病开始于对侧阴性的发病之前，但在老年人中，发病时间大致相同。这一发现模式与观察到的年龄组之间选择错误率的差异一致。总之，运动电位的寿命变化表明，与年轻人相比，儿童和老年人的运动反应控制不佳。(C)2011爱思唯尔有限公司版权所有。
Response speed improves from childhood to early adulthood and declines steadily with advancing age. The present event-related brain potential (ERP) study explored the contribution of the primary motor cortex (M1) to lifespan changes in response speed and accuracy using a choice reaction time (RI) task. Two groups of children (8 and 12 years) and two groups of adults (21 and 76 years) responded to leftor right-pointing arrows. RTs showed a typical U-shaped lifespan pattern. RT was segmented into pre-election time, pre-motor time, and motor time by using the onset of the central motor command (i.e., LRP, and the negative Laplacian potential) and the onset of response-related EMG. Pre-motor time was most sensitive to age-related change. In addition, the positive Laplacian potential, assumed to be associated with inhibition of the incorrect response alternative, was absent in children. In adults, the onset of the ipsilateral positivity started before the onset of the contralateral negativity but in elderly the onsets occurred approximately at the same time. This pattern of findings is consistent with the observed differences in choice error rates between age groups. Taken together, the lifespan changes in motor potentials point to suboptimal motor response control in children and the elderly compared to young adults. (C) 2011 Elsevier B.V. All rights reserved.