Impact of SLC20A1 on the Wnt/β-catenin signaling pathway in somatotroph adenomas
Impact of SLC20A1 on the Wnt/β-catenin signaling pathway in somatotroph adenomas
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DOI：
10.3892/mmr.2019.10555
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发表时间：
2019-10-01
影响因子：
3.4
通讯作者：
Zhang, Yazhuo
中科院分区：
文献类型：
--
作者：
Li, Jianhua;Dong, Wei;Zhang, Yazhuo
研究表明，癌基因、抑癌基因、信号通路和受体的遗传和功能异常是垂体肿瘤发生过程中最重要的事件之一，有效的生物标志物将有助于垂体肿瘤的早期诊断、后续治疗和疾病控制。本研究调查了52例生长激素腺瘤患者溶质载体家族20成员1（也称为磷酸盐转运蛋白1（SLC 20 A1））和Wnt/β-连环蛋白信号通路的表达特征。免疫组化分析显示，浸润性肿瘤标本中SLC 20 A1的H值为222.6 ± 15.2，非浸润性肿瘤标本中为144.5 ± 30.4（P
Studies have revealed that genetic and functional aberrations of oncogenes, tumor-suppressor genes, signaling pathways and receptors are among the most prominent events in pituitary tumorigenesis, and a potent biomarker would be helpful for early diagnosis, subsequent treatment and disease control. The present study investigated the expression signatures of solute carrier family 20 member 1, also known as phosphate transporter 1 (SLC20A1) and the Wnt/beta-catenin signaling pathway in 52 patients with somatotroph adenomas. According to immunohistochemistry analysis, the H-score of SLC20A1 was 222.6 +/- 15.2 in invasive tumor samples and 144.5 +/- 30.4 in non-invasive tumor samples (P