Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery.
Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery.
复制标题
用于多部位脑光传输的发光二极管阵列和发光二极管耦合光纤的设计、构造和利用过程。
DOI：
10.1049/joe.2014.0304
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Boyden,EdwardS
中科院分区：
文献类型：
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作者：
Bernstein,JacobG;Allen,BrianD;Guerra,AlexanderA;Boyden,EdwardS
光遗传学使光能够用于控制活体大脑中遗传靶细胞的活动。光纤可用于将光传递到深层目标，并且发光二极管（LED）可在空间上布置以实现图案化光传递。结合起来，LED耦合光纤阵列可以将图案化的光传递到大脑中的深层目标。本文作者描述了制造LED阵列和LED耦合光纤阵列的工艺流程，解释了关键的光学、电气、热学和机械设计原理，以实现此类多站点可瞄准光学设备的制造、组装和测试。他们还探索辅助策略，如手术自动化方法以及实现低噪声同步电生理学的创新。
Optogenetics enables light to be used to control the activity of genetically targeted cells in the living brain. Optical fibres can be used to deliver light to deep targets, and light‐emitting diodes (LEDs) can be spatially arranged to enable patterned light delivery. In combination, arrays of LED‐coupled optical fibres can enable patterned light delivery to deep targets in the brain. Here the authors describe the process flow for making LED arrays and LED‐coupled optical fibre arrays, explaining key optical, electrical, thermal and mechanical design principles to enable the manufacturing, assembly and testing of such multi‐site targetable optical devices. They also explore accessory strategies such as surgical automation approaches as well as innovations to enable low‐noise concurrent electrophysiology.