Optically addressable single-use microfluidic valves by laser printer lithography
Optically addressable single-use microfluidic valves by laser printer lithography
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DOI：
10.1039/c004980h
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发表时间：
2010-01-01
期刊：
影响因子：
6.1
通讯作者：
Ricco, Antonio J.
中科院分区：
文献类型：
--
作者：
Garcia-Cordero, Jose L.;Kurzbuch, Dirk;Ricco, Antonio J.
我们报告的设计，制造和表征的实际微流体阀制造的激光打印机光刻。这些光流体阀通过将来自固态激光器的光能（具有与CD/DVD驱动器中使用的那些激光器类似的功率特性）引导到打印墨粉的点来打开，其中局部加热在短至500 ms内熔化聚合物层中的孔，连接先前隔离的流体组件或隔室。阀功能，响应时间，和激光输入能量的依赖性的孔口尺寸的环烯烃聚合物（COP）和聚对苯二甲酸乙二醇酯（PET）薄膜的报告。在压力驱动和离心微流体平台上演示了这些光流体阀的实现。此外，这些“一次成型”阀包括连续的聚合物膜，该聚合物膜使用低蒸汽渗透性材料密封隔离流体装置内的芯片上流体体积;我们确认了一个月的时间。光流体阀的制造和集成与一系列聚合物微制造技术兼容，并且应该促进完全集成的、可重构的和自动化的芯片实验室系统的开发，特别是当试剂必须在芯片上存储较长时间时，例如用于医疗诊断设备、芯片实验室合成系统或危险的生化分析平台。
We report the design, fabrication, and characterization of practical microfluidic valves fabricated using laser printer lithography. These optofluidic valves are opened by directing optical energy from a solid-state laser, with similar power characteristics to those used in CD/DVD drives, to a spot of printed toner where localized heating melts an orifice in the polymer layer in as little as 500 ms, connecting previously isolated fluidic components or compartments. Valve functionality, response time, and laser input energy dependence of orifice size are reported for cyclo-olefin polymer (COP) and polyethylene terephthalate (PET) films. Implementation of these optofluidic valves is demonstrated on pressure-driven and centrifugal microfluidic platforms. In addition, these "one-shot'" valves comprise a continuous polymer film that hermetically isolates on-chip fluid volumes within fluidic devices using low-vapor-permeability materials; we confirmed this for a period of one month. The fabrication and integration of optofluidic valves are compatible with a range of polymer microfabrication technologies and should facilitate the development of fully integrated, reconfigurable, and automated lab-on-a-chip systems, particularly when reagents must be stored on chip for extended periods, e.g. for medical diagnostic devices, lab-on-a-chip synthetic systems, or hazardous biochemical analysis platforms.