Deamidation of human proteins
Deamidation of human proteins
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DOI：
10.1073/pnas.221463198
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发表时间：
2001-10-23
影响因子：
11.1
通讯作者：
Robinson, AB
中科院分区：
文献类型：
--
作者：
Robinson, NE;Robinson, AB
天冬酰胺酰和谷氨酰胺酰残基的脱酰胺作用导致肽和蛋白质的电荷和构象发生时间依赖性变化。对 126 种人类蛋白质的代表性集合中的 1,371 个天冬酰胺残基的脱酰胺率进行了定量和经实验验证的预测计算。这些比率表明，脱酰胺作用是相当大比例的人类蛋白质中的一种生物学相关现象。
Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins.