Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.
Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.
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共济失调毛细血管扩张患者携带 Epstein-Barr 病毒的淋巴瘤。
作者：
A. Saemundsen;Berkel Ai;Werner Henle;G. Henle;Maria Anvret;Ozden Sanal;F. Ersoy;Melda Çağlar;George Klein
一例小男孩的肠系膜淋巴结未分化淋巴细胞淋巴瘤伴共济失调毛细血管扩张。eb病毒(EBV)-cRNA/DNA杂交和EBV DNA/DNA再关联动力学分析两项独立测试显示，每个细胞分别有53个和68个EBV基因组当量，与携带EBV基因组的肿瘤相容。由于缺乏合适的材料，无法确定这是多克隆淋巴细胞增生还是单克隆肿瘤。EBV基因组的存在应该在由共济失调-毛细血管扩张和其他免疫缺陷引起的淋巴瘤中寻找。
An undifferentiated lymphocytic lymphoma of mesenteric lymph nodes occurred in a young boy with ataxia-telangiectasia. Two independent tests, Epstein-Barr virus (EBV)-cRNA/DNA hybridisation and EBV DNA/DNA reassociation kinetic analysis, showed 53 and 68 EBV genome equivalents per cell respectively, which was compatible with an EBV-genome-carrying tumour. Whether this was a polyclonal lymphoproliferation or a monoclonal tumour could not be determined owing to lack of suitable material. The presence of EBV genomes should be sought in lymphomas arising in ataxia-telangiectasia and other immunodeficiencies.