Relationship between dose, time, and tumor yield in mouse dimethylhydrazine-induced colon tumorigenesis.
Relationship between dose, time, and tumor yield in mouse dimethylhydrazine-induced colon tumorigenesis.
复制标题
小鼠二甲肼诱导的结肠肿瘤发生中剂量、时间和肿瘤产量之间的关系。
DOI：
10.1016/0304-3835(79)90018-1
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发表时间：
1979
期刊：
影响因子：
9.7
通讯作者：
A. Maskens
中科院分区：
文献类型：
--
作者：
E. Deschner;F. C. Long;A. Maskens
结肠直肠肿瘤的产量和体积的数据，获得了355个连续处死的CF 1小鼠84周后，不同剂量水平的致癌物1，2-二甲基肼二氯化物（DMH）。得出了几个结论：（a）随着DMH剂量的增加，肿瘤产量增加，潜伏期缩短。(b)重复给药后，肿瘤产量迅速累积。(c)即使在DMH治疗后很长时间，新的肿瘤仍继续在结肠和直肠中积累。DMH后，每个结肠的肿瘤数量与延迟之间呈正相关，证实了这一点。此外，当同一只小鼠体内存在多个肿瘤时，它们的大小是分级的，而不是统一的，这些观察结果与两步或多步致癌机制一致。后者意味着DMH在某些细胞内诱导永久性的可传递改变，此后将有进一步改变的风险，这些改变能够引发癌症生长。
Colorectal tumor yield and volume data were obtained using 355 CF1mice serially sacrificed up to 84 weeks following various dose levels of the carcinogen 1,2-dimethylhydrazine dichloride (DMH). Several conclusions were reached: (a) With increasing doses of DMH, there was an increased tumor yield and decreased latency period. (b) With repeated doses, there was a rapidly cumulative tumor yield. (c) New tumors continued to accumulate in the colon and rectum even at long intervals after the DMH treatments. This was substantiated by a positive correlation between the number of tumors per colon and the delay after DMH. In addition, when several tumors were present in the same mouse, their sizes were graded rather than uniform.These observations are consistent with a 2- or multi-step carcinogenesis mechanism. The latter implies that DMH induces a permanent transmissible alteration within some cells which thereafter will be at risk for further alterations capable of initiating cancer growth.