Chronic Q fever in the United States
Chronic Q fever in the United States
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DOI：
10.1128/jcm.02365-05
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发表时间：
2006-06-01
影响因子：
9.4
通讯作者：
Dumler, J. Stephen
中科院分区：
文献类型：
--
作者：
Karakousis, Petros C.;Trucksis, Michele;Dumler, J. Stephen
Infections due to Coxiella burnetti, the causative agent of Q fever, are uncommon in the United States. Cases of chronic Q fever are extremely rare and most often manifest as culture-negative endocarditis in patients with underlying valvular heart disease. We describe a 31-year-old farmer from West Virginia with a history of congenital heart disease and recurrent fevers for 14 months who was diagnosed with Q fever endocarditis based on an extremely high antibody titer against Coxiella burnetti phase I antigen. Despite treatment with doxycycline, he continued to have markedly elevated Coxiella burnetii phase I antibody titers for 10 years after the initial diagnosis. To our knowledge, this case represents the longest follow-up period for a patient with chronic Q fever in the United States. We review all cases of chronic Q fever reported in the United States and discuss important issues pertaining to epidemiology, diagnosis, and management of this disease.
