Diseases associated with human papillomavirus infection
Diseases associated with human papillomavirus infection
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DOI：
10.1016/j.virol.2013.06.007
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Cubie, Heather A.
中科院分区：
文献类型：
--
作者：
Cubie, Heather A.
人乳头瘤病毒（HPV）无处不在，很好地适应了它们的宿主，并巧妙地与免疫反应隔离开来。HPV感染可以是生产性的，亚临床的或潜伏在皮肤和粘膜中。HPV与宫颈癌的因果关系，以及越来越多的男性和女性的其他部位鳞状细胞癌的数量增加，越来越多地被认识到，而皮肤HPV病变的发病率，特别是在免疫抑制人群中也很重要。本章阐述了感染的范围和感染后果的临床表现及其持续性，并描述了为什么HPV既是高效病原体又是致癌物，难以消除。(C)2013 Elsevier Inc. All rights reserved.
Human papillomaviruses (HPVs) are ubiquitous, well adapted to their host and cleverly sequestered away from immune responses. HPV infections can be productive, subclinical or latent in both skin and mucosa. The causal association of HPV with cervical cancer, and increasingly with rising numbers of squamous cell carcinomas at other sites in both men and women, is increasingly recognised, while the morbidity of cutaneous HPV lesions, particularly in the immunosuppressed population is also significant. This chapter sets out the range of infections and clinical manifestations of the consequences of infection and its persistence and describes why HPVs are both highly effective pathogens and carcinogens, challenging to eliminate. (C) 2013 Elsevier Inc. All rights reserved.