The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population.
The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population.
复制标题
RNA剪接复合物基因SF3A1多态性与中国人群结直肠癌风险的关联
DOI：
10.1371/journal.pone.0130377
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhong S
中科院分区：
文献类型：
--
作者：
Chen X;Du H;Liu B;Zou L;Chen W;Yang Y;Zhu Y;Gong Y;Tian J;Li F;Zhong S
背景 异常选择性剪接包括 mRNA 剪接机制成分的改变，这在结肠癌中经常发生。然而，SF3A1（mRNA 剪接机制的关键组成部分）对结直肠癌 (CRC) 风险的作用尚未阐明。方法和结果我们进行了一项以医院为基础的病例对照研究，包含 801 名 CRC 患者和 817 名无癌症对照者，以检查 SF3A1 多态性与中国人群中 CRC 风险之间的关联。根据生物信息学分析和先前的发现，选择了四个候选 SNP（rs10376、rs5753073、rs2839998 和 rs2074733）。结果显示这些 SNP 与 CRC 风险之间没有显着关联（P > 0.05）。此外，基于吸烟和饮酒状况的分层分析没有获得统计学上显着的结果。结论 我们的研究是第一个调查 SF3A1 多态性与 CRC 风险之间关联的研究。结果表明，SF3A1 中的这四个 SNP 与中国人群的 CRC 风险无关，然而，需要进一步的研究来证实我们的发现。
Background Aberrant alternative splicing included alterations in components of the mRNA splicing machinery often occurred in colon cancer. However, the role of SF3A1, one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated. Method and Findings We performed a hospital-based case-control study containing 801 CRC patients and 817 cancer-free controls to examine the association between SF3A1 polymorphisms and CRC risk in a Chinese population. Four candidate SNPs (rs10376, rs5753073, rs2839998 and rs2074733) were selected based on bioinformatics analysis and previous findings. The results showed no significant associations between these SNPs and CRC risk (P > 0.05). Besides, the stratified analysis based on the smoking and alcohol use status obtained no statistically significant results. Conclusion Our study was the first one to investigate the association between SF3A1 polymorphisms and CRC risk. The results suggested these four SNPs in SF3A1 were not associated with CRC risk in a Chinese population, however, further more studies are needed to confirm our findings.
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影响因子：
30.8
作者：
Dunlop MG;Dobbins SE;Farrington SM;Jones AM;Palles C;Whiffin N;Tenesa A;Spain S;Broderick P;Ooi LY;Domingo E;Smillie C;Henrion M;Frampton M;Martin L;Grimes G;Gorman M;Semple C;Ma YP;Barclay E;Prendergast J;Cazier JB;Olver B;Penegar S;Lubbe S;Chander I;Carvajal-Carmona LG;Ballereau S;Lloyd A;Vijayakrishnan J;Zgaga L;Rudan I;Theodoratou E;Colorectal Tumour Gene Identification (CORGI) Consortium;Starr JM;Deary I;Kirac I;Kovacević D;Aaltonen LA;Renkonen-Sinisalo L;Mecklin JP;Matsuda K;Nakamura Y;Okada Y;Gallinger S;Duggan DJ;Conti D;Newcomb P;Hopper J;Jenkins MA;Schumacher F;Casey G;Easton D;Shah M;Pharoah P;Lindblom A;Liu T;Swedish Low-Risk Colorectal Cancer Study Group;Smith CG;West H;Cheadle JP;COIN Collaborative Group;Midgley R;Kerr DJ;Campbell H;Tomlinson IP;Houlston RS
通讯作者：
Houlston RS
影响因子：
30.8
作者：
Jaeger, Emma;Webb, Emily;Tomlinson, Ian
通讯作者：
Tomlinson, Ian
影响因子：
6.6
作者：
Bisognin, Andrea;Pizzini, Silvia;Mandruzzato, Susanna
通讯作者：
Mandruzzato, Susanna
影响因子：
4.7
作者：
Landi, Debora;Gemignani, Federica;Landi, Stefano
通讯作者：
Landi, Stefano
DOI：
10.1073/pnas.0903103106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Hindorff, Lucia A.;Sethupathy, Praveen;Manolio, Teri A.
通讯作者：
Manolio, Teri A.