National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments.
National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments.
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国家心理健康研究所抑郁症治疗合作研究计划。
DOI：
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发表时间：
1989
影响因子：
--
通讯作者：
M. Parloff
中科院分区：
文献类型：
--
作者：
I. Elkin;M. Shea;J. Watkins;S. Imber;S. Sotsky;Collins Jf;D. Glass;P. Pilkonis;W. R. Leber;J. Docherty;S. Fiester;M. Parloff
我们调查了两种简短的心理治疗，人际心理治疗和认知行为治疗，用于治疗门诊患者的研究诊断标准诊断的重性抑郁症。250例患者被随机分配到四个16周的治疗条件之一：人际心理治疗，认知行为治疗，盐酸丙咪嗪加临床管理（作为标准参考治疗），安慰剂加临床管理。所有治疗组的患者在治疗过程中抑郁症状显著减轻，功能改善。终止时的治疗顺序一致，丙咪嗪加临床管理通常效果最好，安慰剂加临床管理最差，两种心理治疗介于两者之间，但通常更接近丙咪嗪加临床管理。在不考虑初始疾病严重程度的总样本分析（主要分析）中，没有证据表明其中一种心理疗法的有效性高于另一种，也没有证据表明任何一种心理疗法的有效性显著低于标准参考治疗丙咪嗪加临床管理。将每种心理疗法与安慰剂加临床管理条件进行比较，人际心理疗法的具体有效性证据有限，而认知行为疗法则没有。人际心理治疗和丙咪嗪加临床管理的上级恢复率均高于安慰剂加临床管理。然而，在平均得分上，在主要分析中，四种治疗之间的有效性几乎没有显著差异。二次分析，其中患者的抑郁症状的严重程度和功能障碍的初始水平进行了二分，有助于解释在主要分析中相对缺乏显着的结果。治疗之间的显着差异，目前只有亚组的患者更严重的抑郁症和功能障碍，在这里，有一些证据表明人际心理治疗的有效性与这些患者和丙咪嗪加临床管理的有效性强有力的证据。相比之下，对于不太严重的抑郁症和功能受损的患者，治疗之间没有显著差异，包括安慰剂加临床管理。
We investigated the effectiveness of two brief psychotherapies, interpersonal psychotherapy and cognitive behavior therapy, for the treatment of outpatients with major depression disorder diagnosed by Research Diagnostic Criteria. Two hundred fifty patients were randomly assigned to one of four 16-week treatment conditions: interpersonal psychotherapy, cognitive behavior therapy, imipramine hydrochloride plus clinical management (as a standard reference treatment), and placebo plus clinical management. Patients in all treatments showed significant reduction in depressive symptoms and improvement in functioning over the course of treatment. There was a consistent ordering of treatments at termination, with imipramine plus clinical management generally doing best, placebo plus clinical management worst, and the two psychotherapies in between but generally closer to imipramine plus clinical management. In analyses carried out on the total samples without regard to initial severity of illness (the primary analyses), there was no evidence of greater effectiveness of one of the psychotherapies as compared with the other and no evidence that either of the psychotherapies was significantly less effective than the standard reference treatment, imipramine plus clinical management. Comparing each of the psychotherapies with the placebo plus clinical management condition, there was limited evidence of the specific effectiveness of interpersonal psychotherapy and none for cognitive behavior therapy. Superior recovery rates were found for both interpersonal psychotherapy and imipramine plus clinical management, as compared with placebo plus clinical management. On mean scores, however, there were few significant differences in effectiveness among the four treatments in the primary analyses. Secondary analyses, in which patients were dichotomized on initial level of severity of depressive symptoms and impairment of functioning, helped to explain the relative lack of significant findings in the primary analyses. Significant differences among treatments were present only for the subgroup of patients who were more severely depressed and functionally impaired; here, there was some evidence of the effectiveness of interpersonal psychotherapy with these patients and strong evidence of the effectiveness of imipramine plus clinical management. In contrast, there were no significant differences among treatments, including placebo plus clinical management, for the less severely depressed and functionally impaired patients.
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地昔帕明对抑郁症门诊患者的疗效。
影响因子：
--
作者：
Stewart,JW;Quitkin,FM;Liebowitz,MR;McGrath,PJ;Harrison,WM;Klein,DF
通讯作者：
Klein,DF
认知疗法和药物疗法。
影响因子：
--
作者：
Murphy,GE;Simons,AD;Wetzel,RD;Lustman,PJ
通讯作者：
Lustman,PJ
影响因子：
5.9
作者：
KAZDIN, AE
通讯作者：
KAZDIN, AE
精神症状的严重程度作为心理治疗获益的预测指标：退伍军人管理局-宾夕法尼亚大学研究。
DOI：
10.1176/ajp.141.10.1172
发表时间：
1984
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Woody,GE;McLellan,AT;Luborsky,L;O'Brien,CP;Blaine,J;Fox,S;Herman,I;Beck,AT
通讯作者：
Beck,AT