Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in nonarteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy
Quantitative assessment of optic nerve head morphology and retinal nerve fibre layer in nonarteritic anterior ischaemic optic neuropathy with optical coherence tomography and confocal scanning laser ophthalmoloscopy
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DOI：
10.1136/bjo.2008.143297
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发表时间：
2009-06-01
影响因子：
4.1
通讯作者：
Lam, D. S. C.
中科院分区：
文献类型：
--
作者：
Chan, C. K. M.;Cheng, A. C. O.;Lam, D. S. C.
背景/目的：使用光学相干断层扫描（OCT）和海德堡视网膜断层扫描仪（HRT）比较非动脉炎性前部缺血性视神经病变（NAION）患者和正常对照的视盘参数，并评估 NAION 眼的结构与功能关系。方法：22 名典型单侧 NAION 持续时间≥6 个月的患者的双眼 随机选取52名正常受试者的52只眼睛进行Humphrey视野（HVF）检查并测量视盘和视网膜神经纤维层厚度（RNFLT）。结果：对于NAION受影响眼、NAION对侧眼和正常对照，眼部放大校正OCT视盘面积分别为1.849（SD 0.343）mm（2）、1.809（0.285） 毫米(2) 和 1.964 (0.386) 毫米(2)；罩杯面积分别为 0.246 (0.187) mm(2)、0.172 (0.180) mm(2) 和 0.469 (0.332) mm(2)。 HRT 时，椎间盘面积分别为 2.11 (0.38) mm(2)、2.06 (0.40) mm(2) 和 2.16 (0.42) mm(2)；罩杯面积分别为 0.28 (0.34) mm(2)、0.25 (0.18) mm(2) 和 0.48 (0.32) mm(2)。在 OCT 和 HRT 上，NAION 患者双眼的杯面积和杯盘面积比 (CDAR) 均显着小于对照组 (p = 0.21)。在 NAION 受影响的眼睛中，HVF 平均偏差与 OCT RNFLT 之间存在显着相关性 (r = 0.44，p = 0.04)，但与 HRT RNFLT (p = 0.30) 之间不存在显着相关性。 结论：与对照组相比，NAION 患者双眼的视杯和 CDAR 较小。需要更大的样本量来证明椎间盘大小是否会影响发生 NAION 的风险。受 NAION 影响的眼睛的 OCT RNFLT 与 HVF 平均偏差相关，但 HRT RNFLT 则不然。
Background/aims: To compare the optic disc parameters between patients with non-arteritic anterior ischaemic optic neuropathy (NAION) and normal controls, using optical coherence tomography (OCT) and Heidelberg Retinal Tomograph III (HRT), and to evaluate the structure-function relationship in NAION eyes.Methods: Both eyes of 22 patients with typical unilateral NAION of >= 6 months' duration and 52 eyes from 52 randomly selected normal subjects underwent Humphrey visual field (HVF) examination and measurement of optic disc and retinal nerve fibre layer thickness (RNFLT).Results: For the NAION-affected eyes, NAION fellow eyes and normal controls, the ocular magnification-corrected OCT disc areas were respectively 1.849 (SD 0.343) mm(2), 1.809 (0.285) mm(2) and 1.964 (0.386) mm(2); the cup areas were 0.246 (0.187) mm(2), 0.172 (0.180) mm(2) and 0.469 (0.332) mm(2). On HRT, the disc areas were 2.11 (0.38) mm(2), 2.06 (0.40) mm(2) and 2.16 (0.42) mm(2); and the cup areas were 0.28 (0.34) mm(2), 0.25 (0.18) mm(2) and 0.48 (0.32) mm(2). On both OCT and HRT, the cup areas and cup-disc area ratios (CDAR) of both eyes of NAION patients were significantly smaller than controls (p = 0.21). There was a significant correlation between HVF mean deviation and OCT RNFLT (r = 0.44, p = 0.04) but not with HRT RNFLT (p = 0.30) in NAION-affected eyes.Conclusion: NAION patients have smaller optic cups and CDARs in both eyes compared with controls. A larger sample size is necessary to demonstrate if disc size affects the risk of developing NAION. The NAION-affected eyes' OCT RNFLT correlated with HVF mean deviation but the HRT RNFLT did not.