Decreased Circulating Levels of Spexin in Obese Children
Decreased Circulating Levels of Spexin in Obese Children
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DOI：
10.1210/jc.2016-1177
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发表时间：
2016-07-01
影响因子：
5.8
通讯作者：
Balagopal, P. Babu
中科院分区：
文献类型：
--
作者：
Kumar, Seema;Hossain, Jobayer;Balagopal, P. Babu
上下文：Spexin是一种新型肽，与动物和成年人的肥胖和相关能量稳态有关。人们对它在儿童中的作用知之甚少。目的：本研究的目的是确定Spexin在肥胖儿童中的潜在作用，并探讨其与各种心脏代谢危险因素的关系。设计和参与者：这是一项由69名儿童组成的横断面研究（51名肥胖儿童，18名正常体重儿童，年龄15.3±0.26岁）。结果测量：Spexin采用特异性酶联免疫吸附法测定。同时测定瘦素、总脂联素和高分子量脂联素、IL-6、高敏c反应蛋白、葡萄糖和胰岛素。使用Mann-Whitney U检验、Pearson和Spearman秩相关、逻辑回归和聚类分析对数据进行分析和解释。结果：肥胖儿童的Spexin水平明显低于正常体重儿童，中位数（IQR） （0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P = 0.024），但与其他脂肪因子和/或胰岛素和葡萄糖水平无关。Spexin的有序分类变量显示肥胖与Spexin水平呈严格的负相关。Spexin和体重指数z评分的聚类分析结果将参与者分为正常体重组和肥胖体重组，准确率很高。结论：与正常体重的儿童相比，肥胖儿童的Spexin循环水平较低，并且根据Spexin浓度区分肥胖和正常体重组的能力使我们提出这种新型肽在儿童肥胖中的潜在作用。这些发现的临床意义有待进一步研究。
Context: Spexin is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in children.Objective: The aim of the current study was to determine the potential role of Spexin in obese children and explore its relationships with various cardiometabolic risk factors.Design and Participants: This was a cross-sectional study composed of 69 children (51 obese and 18 normal weight; age 15.3 +/- 0.26 y).Outcome Measures: Spexin was measured using a specific enzyme-linked immunosorbent assay. Leptin, total and high-molecular-weight adiponectin, IL-6, high-sensitivity C-reactive protein, glucose, and insulin were also measured. Mann-Whitney U test, Pearson and Spearman rank correlations, logistic regression, and cluster analysis were used for the analysis and interpretation of the data.Results: Spexin levels were significantly lower in obese vs normal-weight children, median(IQR) (0.33 ng/mL [0.27-0.44] vs 0.42 ng/mL [0.33-0.55]; P = .024), but did not correlate with other adipokines and/or insulin and glucose levels. Ordinal categorical variables of Spexin showed a strictly reverse association of obesity with the level of Spexin. Cluster analysis of Spexin and body mass index z score resulted in splitting the participants into normal-weight and obese-weight groups with high accuracy.Conclusions: Lower circulating levels of Spexin in obese children compared with their normal-weight counterparts and the ability to discriminate obese and normal-weight groups based on Spexin concentration enabled us to suggest a potential role for this novel peptide in childhood obesity. The clinical significance of these findings needs additional investigation.