Tracking plasma cell differentiation and survival
Tracking plasma cell differentiation and survival
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DOI：
10.1002/cyto.a.22355
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发表时间：
2014-01
期刊：
影响因子：
3.7
通讯作者：
K. Roth;L. Oehme;S. Zehentmeier;Yang Zhang;R. Niesner;A. Hauser
中科院分区：
文献类型：
--
作者：
K. Roth;L. Oehme;S. Zehentmeier;Yang Zhang;R. Niesner;A. Hauser
浆细胞在体液免疫反应中起着至关重要的作用，因为它们代表了身体产生抗体的工厂。从B细胞到浆细胞的分化由复杂的转录网络控制，并且发生在次级淋巴器官内。根据其寿命，可以区分两种类型的抗体分泌细胞：短寿命浆细胞位于次级淋巴器官的滤泡外部位，如淋巴结髓索和脾红髓。一部分浆母细胞从次级淋巴器官迁移到骨髓，在那里它们可以成为长寿的浆细胞。骨髓浆细胞存在于称为生存龛的特殊微解剖环境中，这提供了促进其寿命的因素。网状基质细胞产生趋化因子CXCL 12，它被称为吸引浆母细胞到骨髓，但也促进浆细胞存活，在维持这些小生境中发挥至关重要的作用。此外，造血细胞通过提供其他可溶性存活因子对小生境做出贡献。在这里，我们回顾了目前的知识，在浆细胞分化，其定位和迁移的因素。我们还概述了什么是已知的关于维持长寿的浆细胞在生存龛的骨髓。© 2013国际细胞计数促进学会
Plasma cells play a crucial role for the humoral immune response as they represent the body's factories for antibody production. The differentiation from a B cell into a plasma cell is controlled by a complex transcriptional network and happens within secondary lymphoid organs. Based on their lifetime, two types of antibody secreting cells can be distinguished: Short‐lived plasma cells are located in extrafollicular sites of secondary lymphoid organs such as lymph node medullary cords and the splenic red pulp. A fraction of plasmablasts migrate from secondary lymphoid organs to the bone marrow where they can become long‐lived plasma cells. Bone marrow plasma cells reside in special microanatomical environments termed survival niches, which provide factors promoting their longevity. Reticular stromal cells producing the chemokine CXCL12, which is known to attract plasmablasts to the bone marrow but also to promote plasma cell survival, play a crucial role in the maintenance of these niches. In addition, hematopoietic cells are contributing to the niches by providing other soluble survival factors. Here, we review the current knowledge on the factors involved in plasma cell differentiation, their localization and migration. We also give an overview on what is known regarding the maintenance of long lived plasma cells in survival niches of the bone marrow. © 2013 International Society for Advancement of Cytometry