Serum Micronutrient Status of Haart-Naive, HIV Infected Children in South Western Nigeria: A Case Controlled Study
Serum Micronutrient Status of Haart-Naive, HIV Infected Children in South Western Nigeria: A Case Controlled Study
复制标题
DOI：
10.1155/2014/351043
复制
发表时间：
2014-01-01
影响因子：
1.7
通讯作者：
Adeodu, O. O.
中科院分区：
文献类型：
--
作者：
Anyabolu, H. C.;Adejuyigbe, E. A.;Adeodu, O. O.
背景资料。虽然微量营养素在人类免疫缺陷病毒感染的发病机制中至关重要，但大多数研究都是在成年人身上进行的。了解感染艾滋病毒的非洲儿童的关键微量营养素状况将表明，补充营养是否有益于生活在这一资源匮乏地区的这些儿童。目标。我们试图确定HAART幼稚HIV感染儿童的微量营养素状况及其相关因素，并将其与HIV阴性对照进行比较。方法：研究方法。我们招募了70名明显稳定的HAART幼稚HIV感染儿童。70名年龄和性别匹配的HIV阴性儿童作为对照。对他们的社会阶层、人体测量、临床分期、CD4计数、血清锌、硒和维生素C进行测定。结果。HIV感染者锌、硒和维生素C缺乏率分别为77.1%、71.4%和70.0%，而HIV阴性对照组分别为44.3%、18.6%和15.7%。在HIV感染者中，有58.6%的人三种微量营养素缺乏。微量营养素状况与体重、临床和免疫阶段有关，但与体重指数或社会阶层无关。结论。这些关键微量营养素的缺乏在HAART幼稚的艾滋病毒感染儿童中普遍存在，无论社会阶层如何。这表明补充剂试验研究可能适用于这一人群。
Background. Though micronutrients are vital in the pathogenesis of human immunodeficiency virus infection, most studies have been conducted in adults. Knowledge of the status of key micronutrients in HIV infected African children will indicate if supplementation may be beneficial to these children living in this resource-poor region. Objectives. We sought to determine the micronutrient status and associated factors of HAART-naive HIV infected children and compare them with those of the HIV negative controls. Methods. We enrolled 70 apparently stable HAART naive HIV infected children. Seventy age and sex matched HIV negative children were equally enrolled as the controls. Their social class, anthropometry, clinical stage, CD4 counts, serum zinc, selenium, and vitamin C were determined. Results. The prevalence of zinc, selenium, and vitamin C deficiency in HIV infected subjects was 77.1%, 71.4%, and 70.0%, respectively, as compared to 44.3%, 18.6%, and 15.7% in HIV negative controls. Among the HIV infected subjects, 58.6% were deficient in the three micronutrients. Micronutrient status was related to the weight, clinical, and immunological stages but not BMI or social class. Conclusion. Deficiency of these key micronutrients is widely prevalent in HAART naive HIV infected children irrespective of social class. This suggests that supplementation trial studies may be indicated in this population.