ESHRE guideline: management of women with premature ovarian insufficiency
ESHRE guideline: management of women with premature ovarian insufficiency
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DOI：
10.18370/2309-4117.2017.37.41-48
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发表时间：
2017-10
影响因子：
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通讯作者：
L. Webber;М. Davies;Р. Anderso
中科院分区：
文献类型：
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作者：
L. Webber;М. Davies;Р. Anderso
学习问题。根据文献中现有的最佳证据，卵巢功能不全(POI)患者的最佳治疗方案是什么？研究设计、大小、持续时间。该指南是由该领域的一个多学科专家小组使用《ESHRE指南制定手册》的方法编制的，包括对文献进行彻底的系统搜索，对截至2014年9月的纳入论文进行质量评估，并在指南小组内就所有建议达成共识。草案定稿后，欧洲人类生殖与胚胎学学会(ESHRE)的成员和专业组织被要求审查指南。主要结果иChance的作用。指南制定小组(GDG)制定了99项建议，回答了31个关于POI妇女诊断和治疗的关键问题。该指南就POI的诊断和и评估提供了17项建议，并就POI的不同后遗症及其监测и治疗的后果提出了46项建议。此外，还制定了24项关于POI妇女激素替代疗法的建议，以及两项关于替代и补充治疗的建议。在关于青春期诱导的一章中，有五条建议。限制，谨慎的理由。该指南的主要局限性是，由于缺乏数据，许多建议是基于专家意见或来自对绝经后妇女或患有特纳综合征的妇女的研究的间接证据。尽管存在这些局限性，指南小组相信，根据现有证据，这份文件将能够指导卫生保健专业人员提供管理POI妇女的最佳实践。此外，指导小组还就文献检索中发现的知识差距提出了研究建议，试图促进对POI关键问题的研究。
Study question. What is the optimal management of women with premature ovarian insufficiency (POI) based on the best available evidence in the literature?Study design, size, duration. This guideline was produced by a multidisciplinary group of experts in the field using the methodology of the Manual for ESHRE Guideline Development, including a thorough systematic search of the literature, quality assessment of the included papers up to September 2014 and consensus within the guideline group on all recommendations.The GDG included a patient representative with POI. After finalization of the draft, the European Society for Human Reproduction and Embryology (ESHRE) members and professional organizations were asked to review the guideline.Main results и the role of chance. The guideline development group (GDG) formulated 99 recommendations answering 31 key questions on the diagnosis and treatment of women with POI. The guideline provides 17 recommendations on diagnosis и assessment of POI and 46 recommendations on the different sequelae of POI and their consequences for monitoring и treatment. Furthermore, 24 recommendations were formulated on hormone replacement therapy in women with POI, and two on alternative и complementary treatment. A chapter on puberty induction resulted in five recommendations.Limitations, reasons for caution. The main limitation of the guideline is that, due to the lack of data, many of the recommendations are based on expert opinion or indirect evidence from studies on post-menopausal women or women with Turner Syndrome.Wider implications of the findings. Despite the limitations, the guideline group is confident that this document will be able to guide health care professionals in providing the best practice for managing women with POI given current evidence. Furthermore, the guideline group has formulated research recommendations on the gaps in knowledge identified in the literature searches, in an attempt to stimulate research on the key issues in POI.