Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression
Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their first episode of major depression
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DOI：
10.1016/j.jad.2013.10.021
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发表时间：
2014-02-01
影响因子：
6.6
通讯作者：
Ham, Byung-Joo
中科院分区：
文献类型：
--
作者：
Han, Kyu-Man;Choi, Sunyoung;Ham, Byung-Joo
背景：重度抑郁障碍(MDD)患者大脑的真实形态变化存在不确定性，这凸显了用多模式脑结构成像分析进行综合研究的必要性。本研究旨在评价首发、未服药的MDD患者和健康对照组在皮质厚度、皮质和皮质下体积、白质完整性方面的差异。方法：选择首次发病且病程不超过6个月的MDD患者(n=20)，并与年龄、性别和教育水平的健康对照组(n=22)进行比较。所有受试者均接受T1加权结构磁共振成像(MRL)。结果：首发MDD患者的尾侧扣带回皮质体积明显减小(P
Background: The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and white matter integrity between first episode, medication-naive MDD patients and healthy controls.Methods: Subjects with their first episode of MDD whose illness duration had not exceeded 6 months (n=20) were enrolled in this study and were compared to age-, sex-, and education level marched healthy controls (n=22). All participants were subjected to T1-weighted structural magnetic resonance imaging (MRl). We used an automated procedure of FreeSurfer and Tract-based spatial statistics (TBSS) to analyze differences in cortical thickness, cortical and subcortical volume, and white matter integrity between two groups.Results: The patients with first episode MDD exhibited significantly reduced cortical volume in the caudal anterior cingulate gyrus (P