Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy.
Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy.
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DOI：
10.1007/978-1-0716-2772-3_24
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发表时间：
2023
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糖皮质激素类固醇在营养不良小鼠中的体内测试为这些药物在肌肉营养不良的病理背景下的益处和风险提供了重要的见解。给药频率改变糖皮质激素对肌肉和代谢稳态的作用谱。在这里，我们描述了一种非侵入性和侵入性方法的组合，以定量区分间歇性（每周一次）与主流（每日一次）方案对杜氏和肢带型肌营养不良症小鼠模型肌肉纤维化，肌肉功能和代谢稳态的具体影响。
In vivo testing of glucocorticoid steroids in dystrophic mice offers important insights in benefits and risks of those drugs in the pathological context of muscular dystrophy. Frequency of dosing changes the spectrum of glucocorticoid effects on muscle and metabolic homeostasis. Here we describe a combination of non-invasive and invasive methods to quantitatively discriminate the specific effects of intermittent (once-weekly) versus mainstay (once-daily) regimens on muscle fibrosis, muscle function and metabolic homeostasis in murine models of Duchenne and Limb-Girdle muscular dystrophies.