Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex
Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex
复制标题
DOI：
10.1016/s0925-4773(98)00233-0
复制
发表时间：
1999-03-01
影响因子：
2.6
通讯作者：
Westphal, H
中科院分区：
文献类型：
--
作者：
Bertuzzi, S;Porter, FD;Westphal, H
为了解释在Lhx2突变胚胎中观察到的表型，我们先前提出可能存在Lhx2相关基因。我们现在已经克隆了一个新的LIM/同源盒基因Lhx9。Lhx9与Lhx2密切相关，在发育中的中枢神经系统（CNS）中表达。Lhx9和Lhx2的表达模式在某些区域重叠，但在其他区域不同。因此，在某些发育领域，这两种高度相关的蛋白可能在功能上是冗余的。Lhx9在大脑皮层的先锋神经元中表达，而Lhx2在整个皮质层中表达。出生后，Lhx9在小脑内核表达，而Lhx2在颗粒层表达。在发育中的肢体中，这两个基因以相似的模式高度表达。基于Lhx9的表达模式和发育调控，我们认为Lhx9可能参与了大脑皮层先锋神经元的规范或功能。我们发现Lhx9和Lhx2都能结合LIM结构域结合蛋白Ldb1/Nli1/Clim2。1999爱思唯尔科学爱尔兰有限公司版权所有。
In order to explain the phenotype observed in Lhx2 mutant embryos, we previously proposed that an Lhx2 related gene might exist. We now have cloned a new LIM/homeobox gene called Lhx9. Lhx9 is closely related to Lhx2 and is expressed in the developing central nervous system (CNS). Lhx9 and Lhx2 have expression patterns that overlap in some areas but are distinct in others. Thus, in some developmental domains these two highly related proteins may be functionally redundant. Lhx9 is expressed in the pioneer neurons of the cerebral cortex, while Lhx2 is expressed throughout the cortical layers. Postnatally, Lhx9 is expressed in the inner nuclei of the cerebellum, while Lhx2 is in the granular layer. In the developing limbs, both genes are highly expressed in a similar pattern. Based on the expression pattern and the developmental regulation of Lhx9, we propose that Lhx9 may be involved in the specification or function of the pioneer neurons of the cerebral cortex. We show that both Lhx9 and Lhx2 bind the LIM domain binding protein Ldb1/Nli1/Clim2. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.