Central nervous system and control of endogenous glucose production.
Central nervous system and control of endogenous glucose production.
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DOI：
10.1007/s11892-006-0033-8
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发表时间：
2006-06-01
影响因子：
4.2
通讯作者：
Obici, Silvana
中科院分区：
文献类型：
--
作者：
Demuro, Giovanna;Obici, Silvana
最近的证据表明，中枢神经系统在控制葡萄糖动态平衡方面起着至关重要的作用。参与调节能量平衡和内源性葡萄糖产生的下丘脑中枢通过接收和整合来自循环营养物质和激素(如胰岛素和瘦素)的输入，不断感觉到燃料的可获得性。作为对这些外周信号的反应，下丘脑发出抑制食物摄取和内源性葡萄糖产生的传出冲动。这可以促进能量平衡，并将血糖水平保持在正常范围内。这种错综复杂的神经控制障碍很可能发生在2型糖尿病和肥胖症中，并可能导致这两种疾病常见的葡萄糖稳态和胰岛素抵抗的缺陷。本文综述了有关下丘脑控制内源性葡萄糖产生的最新研究成果，重点介绍了循环中的大量营养素和营养诱导激素的中枢作用。
Recent evidence points to the crucial role of the central nervous system in controlling glucose homeostasis. Hypothalamic centers involved in the regulation of energy balance and endogenous glucose production constantly sense fuel availability by receiving and integrating inputs from circulating nutrients and hormones such as insulin and leptin. In response to these peripheral signals, the hypothalamus sends out efferent impulses that restrain food intake and endogenous glucose production. This promotes energy homeostasis and keeps blood glucose levels in the normal range. Disruption of this intricate neural control is likely to occur in type 2 diabetes and obesity and may contribute to defects of glucose homeostasis and insulin resistance common to both diseases. This review summarizes the latest findings on the hypothalamic control of endogenous glucose production, and focuses on the central effects of circulating macronutrients and nutrient-induced hormones.