PLATELET ADHESION
PLATELET ADHESION
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DOI：
10.1007/978-3-642-60639-7_3
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
G. Escolar
中科院分区：
文献类型：
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作者：
G. Escolar
血小板粘附于受损血管壁是止血和血栓形成的第一步（SixmaandWester 1977;Baumgartneret al. 1976）。血小板粘附之后是扩散和活化，导致α颗粒分泌和聚集体形成。血小板反应的严重程度取决于血管壁病变的程度和暴露于流动血液的成分的相对反应性。血小板通过促进血栓形成在动脉粥样硬化狭窄中起重要作用，导致心肌梗死、中风和心绞痛，但也导致动脉粥样硬化的进一步发展（Daviesanderas 1981; Falk 1985）。血小板的粘附发生在需要独特的细胞粘附机制的流动条件下：血小板粘附必须迅速发生并抵抗剪切力。这导致了一组独特的配体和受体的发展。血小板血管壁相互作用和随后的血小板-血小板相互作用由血小板外膜上的糖蛋白以及血浆、血小板α颗粒和血管壁中存在的粘附蛋白介导。
Platelet adhesion to the damaged vessel wall is the first step in haemostasis and thrombosis (SixmaandWester1977;Baumgartneret al. 1976). Platelet adhesion is followed by spreading and activation, resulting in secretion of theα-granula and aggregate formation. The severity of the platelet reaction is dependent on the extent of the vessel wall lesion and on the relative reactivity of the components that have become exposed to the flowing blood. Platelets play an important role in the atherosclerotic narrowing of arteries by promoting thrombus formation, leading to myocardial infarction, stroke and angina, but also to a further development of atherosclerosis (DaviesandThomas1981;Falk1985). The adhesion of platelets occurs under flow conditions which require a unique cell adhesion mechanism: platelet adhesion has to occur rapidly and resist shear forces. This has led to the development of a unique set of ligands and receptors. Platelet vessel wall interaction and subsequent platelet-platelet interaction are mediated by glycoproteins on the platelet outer membrane and by adhesive proteins present in plasma, plateletα-granules and the vessel wall.