Maternal age and asthma in Latino populations.
Maternal age and asthma in Latino populations.
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DOI：
10.1111/cea.12765
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Kumar R
中科院分区：
文献类型：
--
作者：
Abid Z;Oh SS;Hu D;Sen S;Huntsman S;Eng C;Farber HJ;Rodriguez-Cintron W;Rodriguez-Santana JR;Serebrisky D;Avila PC;Thyne SM;Kim KA;Borrell LN;Williams LK;Seibold MA;Burchard EG;Kumar R
在欧洲血统的人群中，母亲出生时年龄较小与后代患哮喘的风险增加有关，但尚未在拉丁美洲人群中进行研究。我们试图在一项针对拉丁裔儿童的全国性研究中检查母亲出生年龄与哮喘患病率之间的关系。我们纳入了2008年7月至2011年11月从美国5个中心和波多黎各招募的3473名8-21岁的拉丁裔儿童（1696名医生诊断为哮喘的受试者和1777名健康对照者）。我们使用多元logistic回归分析母亲出生时年龄对后代哮喘的影响，以及按种族亚组（墨西哥裔美国人，波多黎各人和其他拉丁美洲人）分层的分析。二次分析评估了兄弟姐妹，文化适应和收入对这种关系的影响。母亲年龄<20岁与后代哮喘发病率降低显著相关，独立于其他危险因素（OR = 0.73，95%CI：0.57-0.93）。在亚组分析中，仅在墨西哥裔美国人中观察到较年轻的孕产妇年龄的保护作用（OR = 0.53，95%CI：0.36，0.79）。在波多黎各人中，母亲年龄较大与哮喘发病率降低相关（OR = 0.65，95%CI：0.44-0.97）。在进一步的分层模型中，墨西哥裔美国人中母亲年龄较低的保护作用仅见于没有哥哥姐姐的儿童（OR = 0.44，95%CI：0.23-0.81）。与欧洲血统人群相比，墨西哥裔美国妇女中，母亲年龄较低与后代哮喘发病率降低相关。哮喘在城市少数民族人群中很常见，但美国不同拉丁裔种族之间患病率不同的潜在因素还不清楚。母亲年龄是可能有助于解释这种差异的一个因素。
Younger maternal age at birth is associated with increased risk of asthma in offspring in European descent populations, but has not been studied in Latino populations. We sought to examine the relationship between maternal age at birth and prevalence of asthma in a nationwide study of Latino children. We included 3473 Latino children aged 8–21 years (1696 subjects with physician-diagnosed asthma and 1777 healthy controls) from five U.S. centers and Puerto Rico recruited from July 2008 through November 2011. We used multiple logistic regression to examine the effect of maternal age at birth on asthma in offspring overall, and in analyses stratified by ethnic subgroup (Mexican American, Puerto Rican, and Other Latino). Secondary analyses evaluated the effects of siblings, acculturation, and income on this relationship. Maternal age <20 years was significantly associated with a decreased odds of asthma in offspring, independent of other risk factors (OR = 0.73, 95% CI: 0.57–0.93). In subgroup analyses, the protective effect of younger maternal age was observed only in Mexican Americans (OR = 0.53, 95% CI: 0.36, 0.79). In Puerto Ricans, older maternal age was associated with a decreased odds of asthma (OR = 0.65, 95% CI: 0.44–0.97). In further stratified models, the protective effect of younger maternal age in Mexican Americans was seen only in children without older siblings (OR = 0.44, 95% CI: 0.23–0.81). In contrast to European descent populations, younger maternal age was associated with a decreased odds of asthma in offspring in Mexican American women. Asthma is common in urban minority populations but the factors underlying the varying prevalence among different Latino ethnicities in the U.S. is not well understood. Maternal age represents one factor which may help explain this variability.
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影响因子：
8
作者：
Akinbami, LJ;Rhodes, JC;Lara, M
通讯作者：
Lara, M
影响因子：
5.1
作者：
Gurka, Matthew J.;Blackman, James A.;Heymann, Peter W.
通讯作者：
Heymann, Peter W.
DOI：
10.1001/archpedi.1997.02170440027005
发表时间：
1997-07-01
影响因子：
--
作者：
FuentesAfflick, E;Lurie, P
通讯作者：
Lurie, P
影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.
影响因子：
5.4
作者：
INFANTERIVARD, C
通讯作者：
INFANTERIVARD, C