The immunological synapse and CD28-CD80 interactions
The immunological synapse and CD28-CD80 interactions
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DOI：
10.1038/ni737
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发表时间：
2001-12-01
影响因子：
30.5
通讯作者：
Dustin, ML
中科院分区：
文献类型：
--
作者：
Bromley, SK;Iaboni, A;Dustin, ML
根据T细胞激活的双信号模型，共刺激分子增强T细胞受体(TCR)信号，而黏附分子增强TCR-MHC-肽识别。CD28的结构和结合特性表明，它可能兼具这两种功能，模糊了黏附分子和共刺激分子之间的区别。我们的结果表明，初始T细胞上的CD28不支持黏附，几乎没有能力直接增强TCR-MHC-肽的相互作用。我们认为，免疫突触的一个关键功能是产生一个有利于强大的二级信号分子(如CD28)相互作用的细胞微环境，而不是依赖于共刺激信号。
According to the two-signal model of T cell activation, costimulatory molecules augment T cell receptor (TCR) signaling, whereas adhesion molecules enhance TCR-MHC-peptide recognition. The structure and binding properties of CD28 imply that it may perform both functions, blurring the distinction between adhesion and costimulatory molecules. Our results show that CD28 on naive T cells does not support adhesion and has little or no capacity for directly enhancing TCR-MHC-peptide interactions. Instead of being dependent on costimulatory signaling, we propose that a key function of the immunological synapse is to generate a cellular microenvironment that favors the interactions of potent secondary signaling molecules, such as CD28.